PMID- 27533883
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20181202
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 32
IP  - 4
DP  - 2017 Apr
TI  - Exposure to an environmentally relevant mixture of organochlorine compounds and 
      polychlorinated biphenyls Promotes hepatic steatosis in male Ob/Ob mice.
PG  - 1399-1411
LID - 10.1002/tox.22334 [doi]
AB  - Hepatic steatosis is recognized as an independent risk factor for the development 
      of cardiovascular disease. While obesity and type 2 diabetes are well-established 
      risk factors in the development of hepatic steatosis, recent studies have 
      revealed exposure to mixtures of persistent organic pollutants (POPs), which are 
      environmental contaminants in various fatty foods, can promote steatosis. Thus, 
      the present study was designed to determine if exposure to a defined mixture of 
      prevalent polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides or 
      their metabolites promote hepatic steatosis in a genetically induced model of 
      type 2 diabetes, the leptin-deficient ob/ob mouse. Male C57BL/6J wild type (WT) 
      or ob/ob mice were administered an environmentally relevant mixture of PCBs and 
      OCs for 7 weeks via oral gavage. Exposure to POPs did not significantly alter 
      fasting serum glucose or insulin levels. However, POPs exposure significantly 
      increased hepatic triglyceride content in ob/ob animals, while decreasing serum 
      triglyceride levels. This POPs-mediated increase in hepatic triglyceride content 
      did not appear to be associated with significantly increased inflammation in 
      either the liver or adipose. Exposure to POPs significantly induced the 
      expression of cytochrome P450 3a11 in WT animals, yet the expression of this 
      cytochrome was significantly downregulated in ob/ob animals regardless of POPs 
      exposure. Taken together, the present data indicate exposure to an 
      environmentally relevant mixture of both PCBs and OC pesticides in ob/ob mice 
      promotes hepatic steatosis while decreasing hypertriglyceridemia, which 
      demonstrates exposure to a defined mixture of POPs alters systemic lipid 
      metabolism in a genetically induced model of obesity and type 2 diabetes. (c) 2016 
      Wiley Periodicals, Inc. Environ Toxicol 32: 1399-1411, 2017.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Mulligan, Charlee
AU  - Mulligan C
AD  - Department of Basic Sciences, Mississippi State University, College of Veterinary 
      Medicine, Mississippi State, Mississippi, 39762.
FAU - Kondakala, Sandeep
AU  - Kondakala S
AD  - Department of Basic Sciences, Mississippi State University, College of Veterinary 
      Medicine, Mississippi State, Mississippi, 39762.
FAU - Yang, Eun-Ju
AU  - Yang EJ
AD  - Department of Basic Sciences, Mississippi State University, College of Veterinary 
      Medicine, Mississippi State, Mississippi, 39762.
FAU - Stokes, John V
AU  - Stokes JV
AD  - Department of Basic Sciences, Mississippi State University, College of Veterinary 
      Medicine, Mississippi State, Mississippi, 39762.
FAU - Stewart, James A
AU  - Stewart JA
AD  - Department of Basic Sciences, Mississippi State University, College of Veterinary 
      Medicine, Mississippi State, Mississippi, 39762.
FAU - Kaplan, Barbara L F
AU  - Kaplan BL
AD  - Department of Basic Sciences, Mississippi State University, College of Veterinary 
      Medicine, Mississippi State, Mississippi, 39762.
FAU - Howell, George E 3rd
AU  - Howell GE 3rd
AUID- ORCID: 0000-0001-8761-976X
AD  - Department of Basic Sciences, Mississippi State University, College of Veterinary 
      Medicine, Mississippi State, Mississippi, 39762.
LA  - eng
PT  - Journal Article
DEP - 20160817
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
RN  - 0 (Triglycerides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/metabolism/pathology
MH  - Environmental Pollutants/*toxicity
MH  - Fatty Liver/*chemically induced/metabolism
MH  - Lipid Metabolism
MH  - Male
MH  - Metabolic Syndrome/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Obesity/metabolism/pathology
MH  - Pesticides/*toxicity
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - hepatic steatosis
OT  - inflammation
OT  - metabolic syndrome
OT  - persistent organic pollutants
OT  - triglyceride
OT  - type 2 diabetes
EDAT- 2016/08/18 06:00
MHDA- 2017/05/16 06:00
CRDT- 2016/08/18 06:00
PHST- 2016/05/13 00:00 [received]
PHST- 2016/07/25 00:00 [revised]
PHST- 2016/07/30 00:00 [accepted]
PHST- 2016/08/18 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/08/18 06:00 [entrez]
AID - 10.1002/tox.22334 [doi]
PST - ppublish
SO  - Environ Toxicol. 2017 Apr;32(4):1399-1411. doi: 10.1002/tox.22334. Epub 2016 Aug 
      17.