PMID- 27534387
OWN - NLM
STAT- MEDLINE
DCOM- 20170127
LR  - 20170127
IS  - 1474-8673 (Electronic)
IS  - 1474-8665 (Linking)
VI  - 36
IP  - 1-2
DP  - 2016 Jan
TI  - Investigation of gender differences in the cardiovascular actions of direct and 
      indirect sympathomimetic stimulants including cathinone in the anaesthetized rat.
PG  - 14-9
LID - 10.1111/aap.12043 [doi]
AB  - We have studied gender differences in the direct and indirect sympathomimetic 
      cardiovascular effects of the stimulant cathinone (from Khat) (and for comparison 
      methylenedioxymethamphetamine [MDMA]) and the archetypal indirect sympathomimetic 
      agent tyramine, employing male and female Wistar rats. Animals were 
      sympathectomized by treatment with 6-hydroxydopamine or treated with vehicle. In 
      male and female vehicle-treated pentobarbitone-anaesthetized rats, all three 
      agonists (0.001-1 mg/kg) produced significant tachycardia, tyramine produced 
      large pressor, and in high doses small depressor responses, MDMA produced small 
      pressor responses, and cathinone produced only minor pressor effects. In 
      sympathectomized rats, pressor responses, even those to tyramine, were virtually 
      abolished, and depressor responses to tyramine were abolished. In vehicle-treated 
      rats, the tachycardia to tyramine, but not the tachycardia to cathinone or MDMA, 
      was significantly greater in male than female rats. This may suggest that the 
      mechanism of the tachycardia to tyramine differs from those of the stimulants 
      cathinone and MDMA. Following sympathectomy, there were no differences between 
      male and female rats in the tachycardia to any agent. Hence, there were gender 
      differences in the tachycardia response for tyramine, but no gender differences 
      in the cardiovascular responses to the widely used recreational stimulants 
      cathinone and MDMA. Cardiac stimulant actions of cathinone and MDMA were similar 
      in male and female rats.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Alsufyani, H A
AU  - Alsufyani HA
AD  - Department of Physiology, Royal College of Surgeons in Ireland, Dublin, Ireland.
AD  - Department of Physiology, King Abdulaziz University, Jeddah, Kingdom of Saudi 
      Arabia.
FAU - Docherty, J R
AU  - Docherty JR
AD  - Department of Physiology, Royal College of Surgeons in Ireland, Dublin, Ireland. 
      docherty@rcsi.ie.
LA  - eng
PT  - Journal Article
DEP - 20160818
PL  - England
TA  - Auton Autacoid Pharmacol
JT  - Autonomic & autacoid pharmacology
JID - 101157306
RN  - 0 (Adjuvants, Anesthesia)
RN  - 0 (Alkaloids)
RN  - 0 (Sympathomimetics)
RN  - 540EI4406J (cathinone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adjuvants, Anesthesia/*pharmacology
MH  - Alkaloids/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects/physiology
MH  - Cardiovascular Physiological Phenomena/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Heart Rate/drug effects/physiology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - *Sex Characteristics
MH  - Sympathomimetics/*pharmacology
OTO - NOTNLM
OT  - cathinone
OT  - indirect sympathomimetic
OT  - methylenedioxymethamphetamine
OT  - noradrenaline transporter
OT  - sympathectomy
OT  - tyramine
EDAT- 2016/08/19 06:00
MHDA- 2017/01/28 06:00
CRDT- 2016/08/19 06:00
PHST- 2016/05/12 00:00 [received]
PHST- 2016/06/15 00:00 [revised]
PHST- 2016/06/22 00:00 [accepted]
PHST- 2016/08/19 06:00 [entrez]
PHST- 2016/08/19 06:00 [pubmed]
PHST- 2017/01/28 06:00 [medline]
AID - 10.1111/aap.12043 [doi]
PST - ppublish
SO  - Auton Autacoid Pharmacol. 2016 Jan;36(1-2):14-9. doi: 10.1111/aap.12043. Epub 
      2016 Aug 18.