PMID- 27534825
OWN - NLM
STAT- MEDLINE
DCOM- 20170621
LR  - 20171128
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 139
IP  - 3
DP  - 2016 Nov
TI  - HDAC1 negatively regulates Bdnf and Pvalb required for parvalbumin interneuron 
      maturation in an experience-dependent manner.
PG  - 369-380
LID - 10.1111/jnc.13773 [doi]
AB  - During early postnatal development, neuronal circuits are sculpted by sensory 
      experience provided by the external environment. This experience-dependent 
      regulation of circuitry development consolidates the balance of 
      excitatory-inhibitory (E/I) neurons in the brain. The cortical barrel-column that 
      innervates a single principal whisker is used to provide a clear reference frame 
      for studying the consolidation of E/I circuitry. Sensory deprivation of S1 at 
      birth disrupts the consolidation of excitatory-inhibitory balance by decreasing 
      inhibitory transmission of parvalbumin interneurons. The molecular mechanisms 
      underlying this decrease in inhibition are not completely understood. Our 
      findings show that epigenetic mechanisms, in particular histone deacetylation by 
      histone deacetylases, negatively regulate the expression of brain-derived 
      neurotrophic factor (Bdnf) and parvalbumin (Pvalb) genes during development, 
      which are required for the maturation of parvalbumin interneurons. After whisker 
      deprivation, increased histone deacetylase 1 expression and activity led to 
      increased histone deacetylase 1 binding and decreased histone acetylation at Bdnf 
      promoters I-IV and Pvalb promoter, resulting in the repression of Bdnf and Pvalb 
      gene transcription. The decrease in Bdnf expression further affected parvalbumin 
      interneuron maturation at layer II/III in S1, demonstrated by decreased 
      parvalbumin expression, a marker for parvalbumin interneuron maturation. 
      Knockdown of HDAC1 recovered Bdnf and Pvalb gene transcription and also prevented 
      the decrease of inhibitory synapses accompanying whisker deprivation.
CI  - (c) 2016 International Society for Neurochemistry.
FAU - Koh, Dawn X P
AU  - Koh DX
AD  - National University of Singapore, Graduate School of Integrative Sciences and 
      Engineering, Singapore, Singapore.
AD  - Singapore Institute of Clinical Sciences (SICS), A*STAR, Brenner Centre for 
      Molecular Medicine, Singapore, Singapore.
AD  - Department of Pharmacology, National University of Singapore, Yong Loo Lin School 
      of Medicine, Singapore, Singapore.
FAU - Sng, Judy C G
AU  - Sng JC
AUID- ORCID: 0000-0002-6740-6940
AD  - Singapore Institute of Clinical Sciences (SICS), A*STAR, Brenner Centre for 
      Molecular Medicine, Singapore, Singapore. phcsngj@nus.edu.sg.
AD  - Department of Pharmacology, National University of Singapore, Yong Loo Lin School 
      of Medicine, Singapore, Singapore. phcsngj@nus.edu.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160915
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Parvalbumins)
RN  - 0 (RNA, Messenger)
RN  - EC 3.5.1.98 (Hdac1 protein, mouse)
RN  - EC 3.5.1.98 (Histone Deacetylase 1)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Epigenesis, Genetic/physiology
MH  - Histone Deacetylase 1/deficiency/genetics/*metabolism
MH  - Interneurons/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neural Pathways/growth & development
MH  - Parvalbumins/genetics/*metabolism/*physiology
MH  - Pyramidal Cells/metabolism
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Sensation
MH  - Sensory Deprivation
MH  - Somatosensory Cortex/growth & development/physiology
MH  - Vibrissae/innervation/physiology
OTO - NOTNLM
OT  - deprivation
OT  - development
OT  - epigenetics
OT  - inhibitory
OT  - somatosensory
OT  - whisker
EDAT- 2016/10/25 06:00
MHDA- 2017/06/22 06:00
CRDT- 2016/08/19 06:00
PHST- 2016/01/11 00:00 [received]
PHST- 2016/06/24 00:00 [revised]
PHST- 2016/08/10 00:00 [accepted]
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2017/06/22 06:00 [medline]
PHST- 2016/08/19 06:00 [entrez]
AID - 10.1111/jnc.13773 [doi]
PST - ppublish
SO  - J Neurochem. 2016 Nov;139(3):369-380. doi: 10.1111/jnc.13773. Epub 2016 Sep 15.