PMID- 27536141
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160818
LR  - 20200930
IS  - 1178-6930 (Print)
IS  - 1178-6930 (Electronic)
IS  - 1178-6930 (Linking)
VI  - 9
DP  - 2016
TI  - Comparison of planning target volumes based on three-dimensional and 
      four-dimensional CT imaging of thoracic esophageal cancer.
PG  - 4785-91
LID - 10.2147/OTT.S104315 [doi]
AB  - BACKGROUND AND PURPOSE: To investigate the definition of planning target volumes 
      (PTVs) based on four-dimensional computed tomography (4DCT) compared with 
      conventional PTV definition and PTV definition using asymmetrical margins for 
      thoracic primary esophageal cancer. MATERIALS AND METHODS: Forty-three patients 
      with esophageal cancer underwent 3DCT and 4DCT simulation scans during free 
      breathing. The motions of primary tumors located in the proximal (group A), 
      middle (group B), and distal (group C) thoracic esophagus were obtained from the 
      4DCT scans. PTV3D was defined on 3DCT using the tumor motion measured based on 
      4DCT, PTV conventional (PTVconv) was defined on 3DCT by adding a 1.0 cm margin to 
      the clinical target volume, and PTV4D was defined as the union of the target 
      volumes contoured on the ten phases of the 4DCT images. The centroid positions, 
      volumetric differences, and dice similarity coefficients were evaluated for all 
      PTVs. RESULTS: The median centroid shifts between PTV3D and PTV4D and between 
      PTVconv and PTV4D in all three dimensions were <0.3 cm for the three groups. The 
      median size ratios of PTV4D to PTV3D were 0.80, 0.88, and 0.71, and PTV4D to 
      PTVconv were 0.67, 0.73, and 0.76 (chi (2)=-3.18, -2.98, and -3.06; P=0.001, 0.003, 
      and 0.002) for groups A, B, and C, respectively. The dice similarity coefficients 
      were 0.87, 0.90, and 0.81 between PTV4D and PTV3D and 0.80, 0.84, and 0.83 
      between PTV4D and PTVconv (chi (2) =-3.18, -2.98, and -3.06; P=0.001, 0.003, and 
      0.002) for groups A, B, and C, respectively. The difference between the degree of 
      inclusion of PTV4D in PTV3D and that of PTV4D in PTVconv was <2% for all groups. 
      Compared with PTVconv, the amount of irradiated normal tissue for PTV3D was 
      decreased by 11.81% and 11.86% in groups A and B, respectively, but was increased 
      by 2.93% in group C. CONCLUSION: For proximal and middle esophageal cancer, 
      3DCT-based PTV using asymmetrical margins provides good coverage of PTV4D; 
      however, for distal esophageal cancer, 3DCT-based PTV using conventional margins 
      provides ideal conformity with PTV4D.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong 
      University, Shandong Academy of Medical Sciences, Shandong, People's Republic of 
      China.
FAU - Li, Jianbin
AU  - Li J
AD  - Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong 
      University, Shandong Academy of Medical Sciences, Shandong, People's Republic of 
      China.
FAU - Zhang, Yingjie
AU  - Zhang Y
AD  - Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong 
      University, Shandong Academy of Medical Sciences, Shandong, People's Republic of 
      China.
FAU - Shao, Qian
AU  - Shao Q
AD  - Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong 
      University, Shandong Academy of Medical Sciences, Shandong, People's Republic of 
      China.
FAU - Xu, Min
AU  - Xu M
AD  - Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong 
      University, Shandong Academy of Medical Sciences, Shandong, People's Republic of 
      China.
FAU - Fan, Tingyong
AU  - Fan T
AD  - Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong 
      University, Shandong Academy of Medical Sciences, Shandong, People's Republic of 
      China.
FAU - Wang, Jinzhi
AU  - Wang J
AD  - Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong 
      University, Shandong Academy of Medical Sciences, Shandong, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20160802
PL  - New Zealand
TA  - Onco Targets Ther
JT  - OncoTargets and therapy
JID - 101514322
PMC - PMC4976909
OTO - NOTNLM
OT  - 3DCT
OT  - 4DCT
OT  - esophageal carcinoma
OT  - planning target volume
EDAT- 2016/08/19 06:00
MHDA- 2016/08/19 06:01
PMCR- 2016/08/02
CRDT- 2016/08/19 06:00
PHST- 2016/08/19 06:00 [entrez]
PHST- 2016/08/19 06:00 [pubmed]
PHST- 2016/08/19 06:01 [medline]
PHST- 2016/08/02 00:00 [pmc-release]
AID - ott-9-4785 [pii]
AID - 10.2147/OTT.S104315 [doi]
PST - epublish
SO  - Onco Targets Ther. 2016 Aug 2;9:4785-91. doi: 10.2147/OTT.S104315. eCollection 
      2016.