PMID- 27536321
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160818
LR  - 20200930
IS  - 1710-1484 (Print)
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Linking)
VI  - 12
DP  - 2016
TI  - Investigation of anti-asthmatic potential of dried fruits of Vitis vinifera L. in 
      animal model of bronchial asthma.
PG  - 42
LID - 10.1186/s13223-016-0145-x [doi]
LID - 42
AB  - BACKGROUND: Fruits of Vitis vinifera L., commonly known as grapes, are largely 
      consumed worldwide because of their high nutritional and medicinal benefits. 
      CONTEXT AND PURPOSE: The present study investigated effects of V. vinifera fruits 
      in ovalbumin-induced animal model of bronchial asthma. METHODS: Male wistar rats 
      (except group 1) were sensitized with allergen (ovalbumin, 40 mg/rat + aluminum 
      hydroxide, 2 mg/rat). Groups of sensitized animals were treated orally with 
      either vehicle (0.4 mL/kg), standard dexamethasone (2.5 mg/kg) or alcoholic 
      extract of V. vinifera dried fruits (31 and 42.5 mg/kg) from day 1 to 28 (n = 6 
      for all groups). Inflammatory markers including cell counts, cytokines such as 
      interleukin (IL)-4, IL-5, IL-1beta, tumor necrosis factor, immunoglobulin E (IgE), 
      leukotrienes and nitrite levels in both blood/serum and bronchoalveolar fluid 
      were analysed. Breathing rate and tidal volume as lung function parameters were 
      examined by spirometer. Lung tissues were studied for histamine content and 
      histopathology. RESULTS: Treatment of sensitized animals with dexamethasone or 
      two doses of V. vinifera fruits extract inhibited recruitment of inflammatory 
      cytokines, IgE, nitrites and circulating cells particularly eosinophils in 
      blood/serum and bronchoalveolar fluid (p < 0.001, p < 0.01 and p < 0.05). 
      Dexamethasone and V. vinifera fruits extract treatment also normalized lung 
      functions and histamine levels compared to ovalbumin-sensitized controls 
      (p < 0.05 and p < 0.01). Moreover, both drugs exhibited protection against airway 
      inflammation in lung histology. CONCLUSION: Results of study demonstrate the 
      effectiveness of V. vinifera fruits in allergic asthma possibly related to its 
      ability to inhibit cellular response and subsequent production of inflammatory 
      cytokines.
FAU - Arora, Poonam
AU  - Arora P
AUID- ORCID: 0000-0002-4118-8180
AD  - Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia 
      Hamdard (Hamdard University), New Delhi, 110062 India.
FAU - Ansari, S H
AU  - Ansari SH
AD  - Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia 
      Hamdard (Hamdard University), New Delhi, 110062 India.
FAU - Najmi, Abul Kalam
AU  - Najmi AK
AD  - Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard 
      University), New Delhi, 110062 India.
FAU - Anjum, Varisha
AU  - Anjum V
AD  - Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia 
      Hamdard (Hamdard University), New Delhi, 110062 India.
FAU - Ahmad, Sayeed
AU  - Ahmad S
AD  - Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia 
      Hamdard (Hamdard University), New Delhi, 110062 India.
LA  - eng
PT  - Journal Article
DEP - 20160817
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
PMC - PMC4988050
OTO - NOTNLM
OT  - Allergen
OT  - Bronchial asthma
OT  - Histamine
OT  - Lung function
OT  - Vitis vinifera
EDAT- 2016/08/19 06:00
MHDA- 2016/08/19 06:01
PMCR- 2016/08/17
CRDT- 2016/08/19 06:00
PHST- 2016/03/30 00:00 [received]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2016/08/19 06:00 [entrez]
PHST- 2016/08/19 06:00 [pubmed]
PHST- 2016/08/19 06:01 [medline]
PHST- 2016/08/17 00:00 [pmc-release]
AID - 145 [pii]
AID - 10.1186/s13223-016-0145-x [doi]
PST - epublish
SO  - Allergy Asthma Clin Immunol. 2016 Aug 17;12:42. doi: 10.1186/s13223-016-0145-x. 
      eCollection 2016.