PMID- 27536696
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160818
LR  - 20200930
IS  - 2296-9381 (Print)
IS  - 2296-9357 (Electronic)
IS  - 2296-9357 (Linking)
VI  - 2
IP  - 2
DP  - 2016 Jun
TI  - Homocysteine in Renal Injury.
PG  - 80-7
LID - 10.1159/000444900 [doi]
AB  - BACKGROUND: Homocysteine (Hcy) is an intermediate of methionine metabolism. 
      Hyperhomocysteinemia (HHcy) can result from a deficiency in the enzymes or 
      vitamin cofactors required for Hcy metabolism. Patients with renal disease tend 
      to be hyperhomocysteinemic, particularly as renal function declines, although the 
      underlying cause of HHcy in renal disease is not entirely understood. SUMMARY: 
      HHcy is considered a risk or pathogenic factor in the progression of chronic 
      kidney disease (CKD) as well as the cardiovascular complications. KEY MESSAGES: 
      In this review, we summarize both clinical and experimental findings that reveal 
      the contribution of Hcy as a pathogenic factor to the development of CKD. In 
      addition, we discuss several important mechanisms mediating the pathogenic action 
      of Hcy in the kidney, such as local oxidative stress, endoplasmic reticulum 
      stress, inflammation and hypomethylation.
FAU - Long, Yanjun
AU  - Long Y
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, Guiyang, PR China; Division of Nephrology, Guizhou 
      Provincial People's Hospital, Guizhou Provincial Institute of Nephritic and 
      Urinary Disease, Guiyang, PR China.
FAU - Nie, Jing
AU  - Nie J
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, Guiyang, PR China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160427
PL  - Switzerland
TA  - Kidney Dis (Basel)
JT  - Kidney diseases (Basel, Switzerland)
JID - 101658365
PMC - PMC4947689
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Endoplasmic reticulum stress
OT  - Hyperhomocysteinemia
OT  - Hypomethylation
OT  - Oxidative stress
EDAT- 2016/08/19 06:00
MHDA- 2016/08/19 06:01
PMCR- 2017/06/01
CRDT- 2016/08/19 06:00
PHST- 2016/01/06 00:00 [received]
PHST- 2016/02/23 00:00 [accepted]
PHST- 2016/08/19 06:00 [entrez]
PHST- 2016/08/19 06:00 [pubmed]
PHST- 2016/08/19 06:01 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - kdd-0002-0080 [pii]
AID - 10.1159/000444900 [doi]
PST - ppublish
SO  - Kidney Dis (Basel). 2016 Jun;2(2):80-7. doi: 10.1159/000444900. Epub 2016 Apr 27.