PMID- 27537245
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20221207
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 33
IP  - 2
DP  - 2017 Feb
TI  - Glycated albumin and ratio of glycated albumin to glycated hemoglobin are good 
      indicators of diabetic nephropathy in type 2 diabetes mellitus.
LID - 10.1002/dmrr.2843 [doi]
AB  - BACKGROUND: We investigated the association between serum levels of glycated 
      albumin (GA), glycated hemoglobin (HbA(1c) ), and GA:HbA(1c) ratio and the 
      presence of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus 
      (T2DM). METHODS: Two hundred six consecutive patients with T2DM were enrolled 
      from the endocrinology ward at Shengjing Hospital of China Medical University and 
      classified into 2 groups: DN group (n = 71) and non-diabetic nephropathy (non-DN) 
      group (n = 135). RESULTS: The DN group showed significantly higher GA and 
      GA:HbA(1c) values compared with the non-DN group. After univariate logistic 
      regression, GA, GA:HbA(1c) , HbA(1c) , age, T2DM duration, systolic blood 
      pressure, diastolic blood pressure, triglycerides, mean blood glucose (from 7 
      blood glucose checks), and presence of retinopathy were selected for advanced 
      analysis. A multivariate logistic regression analysis was performed to examine 
      the association between the presence of DN and these variables. Glycated albumin, 
      GA:HbA(1c) , duration, systolic blood pressure, mean blood glucose, and 
      retinopathy (but not HbA(1c) ) were identified as independent variables that 
      predicted the presence of DN. We then fitted the areas under the curve of 
      GA:HbA(1c) and GA (0.811 and 0.754, respectively) separately using a receiver 
      operating characteristic curve analysis. Both were better than HbA(1c) (0.580). 
      We defined the cutoff value of GA:HbA(1c) as 2.71 (sensitivity 0.676, specificity 
      0.778) and that of GA as 17.5% (sensitivity 0.761, specificity 0.644) for the 
      prediction of DN in patients with T2DM. CONCLUSIONS: The GA:HbA(1c) ratio and GA 
      may be superior to HbA(1c) associated with the presence of DN.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Wang, Nana
AU  - Wang N
AD  - Endocrinology Department, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Xu, Zhen
AU  - Xu Z
AD  - Laboratory Medicine Department, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Han, Ping
AU  - Han P
AD  - Endocrinology Department, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Li, Tiegang
AU  - Li T
AD  - Emergency Department, Shengjing Hospital of China Medical University, Shenyang, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20160926
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Serum Albumin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Aged
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/blood/*diagnosis/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/analysis/*metabolism
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Serum Albumin/*metabolism
MH  - Glycated Serum Albumin
OTO - NOTNLM
OT  - diabetic nephropathy
OT  - glycated albumin
OT  - hemoglobin A1c
OT  - ratio of glycated albumin to hemoglobin
OT  - type 2 diabetes mellitus
EDAT- 2016/08/19 06:00
MHDA- 2017/09/28 06:00
CRDT- 2016/08/19 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2016/06/26 00:00 [revised]
PHST- 2016/08/15 00:00 [accepted]
PHST- 2016/08/19 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2016/08/19 06:00 [entrez]
AID - 10.1002/dmrr.2843 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2017 Feb;33(2). doi: 10.1002/dmrr.2843. Epub 2016 Sep 26.