PMID- 27538706
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20191210
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 27
IP  - 4
DP  - 2017 Jul
TI  - Clinical characteristics of and risk factors for serious infection in Japanese 
      patients within six months of remission induction therapy for antineutrophil 
      cytoplasmic antibody-associated vasculitis registered in a nationwide, 
      prospective, inception cohort study.
PG  - 646-651
LID - 10.1080/14397595.2016.1226468 [doi]
AB  - OBJECTIVES: The purpose of this study was to identify the clinical 
      characteristics and predictors of serious infections (SIs) in the RemIT-JAV, a 
      nationwide, prospective, inception cohort study for Japanese patients with 
      antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: We 
      analyzed SIs within six months of remission induction therapy in 156 AAV 
      patients. Hazard ratios with 95% confidence intervals (CIs) for SIs were 
      calculated using the COX proportional hazard model. RESULTS: Sixty-three SIs in 
      42 patients were identified. The incidence rate (IR) of SIs was 87.59/100 
      patient-years. The median length of time to the onset of first SIs was 54 days. 
      Hazard ratios (95%CI) for SIs were 1.97 (0.99-3.95) for age >65 years, 0.47 
      (0.25-0.89) for female sex, 2.11 (1.05-4.27) for the severe form of AAV, and 2.88 
      (1.49-5.88) for initial PSL >0.8 mg/kg/day in the first model, and 2.64 
      (1.39-5.01) for smoking and 3.27 (1.66-6.45) for initial PSL >0.8 mg/kg/day in 
      the second model. CONCLUSIONS: Lowering the IR of SIs in Japanese AAV patients is 
      mandatory to improve the vital prognosis of these patients. For remission 
      induction therapy of AAV patients with these risk factors, risk management of 
      immunosuppressive treatment should be carefully considered.
FAU - Watanabe-Imai, Kaori
AU  - Watanabe-Imai K
AD  - a Department of Pharmacovigilance.
AD  - b Department of Medicine and Rheumatology , Graduate School of Medical and Dental 
      Sciences, Tokyo Medical Dental University , Bunkyo-ku , Tokyo , Japan.
FAU - Harigai, Masayoshi
AU  - Harigai M
AD  - a Department of Pharmacovigilance.
AD  - b Department of Medicine and Rheumatology , Graduate School of Medical and Dental 
      Sciences, Tokyo Medical Dental University , Bunkyo-ku , Tokyo , Japan.
FAU - Sada, Ken-Ei
AU  - Sada KE
AD  - c Department of Nephrology, Rheumatology, Endocrinology and Metabolism , Okayama 
      University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 
      Kita-ku , Okayama , Japan.
FAU - Yamamura, Masahiro
AU  - Yamamura M
AD  - d Centor for Rheumatology, Okayama Saiseikai Hospital , Kita-ku , Okayama , 
      Japan.
FAU - Fujii, Takao
AU  - Fujii T
AD  - e Department of the Control for Rheumatic Diseases , Graduate School of Medicine, 
      Kyoto University , Kyoto , Japan.
FAU - Dobashi, Hiroaki
AU  - Dobashi H
AD  - f Division of Hematology, Rheumatology and Respiratory Medicine, Department of 
      Internal Medicine, Faculty of Medicine , Kagawa University , Kida-gun , Kagawa , 
      Japan.
FAU - Amano, Koichi
AU  - Amano K
AD  - g Department of Rheumatology and Clinical Immunology , Saitama Medical Center, 
      Saitama Medical University , Kawagoe, Saitama , Japan.
FAU - Ito, Satoshi
AU  - Ito S
AD  - h Department of Internal Medicine, Faculty of Medicine , University of Tsukuba , 
      Tsukuba , Ibaraki , Japan.
FAU - Homma, Sakae
AU  - Homma S
AD  - i Department of Respiratory Medicine , Toho University Omori Medical Center , 
      Ota-ku , Tokyo , Japan.
FAU - Kumagai, Shunichi
AU  - Kumagai S
AD  - j Department of Clinical Pathology and Immunology, Graduate School of Medicine , 
      Kobe University , Kobe , Hyogo , Japan.
FAU - Banno, Shogo
AU  - Banno S
AD  - k Division of Rheumatology and Nephrology , Aichi Medical University School of 
      Medicine , Nagakute , Aichi , Japan.
FAU - Arimura, Yoshihiro
AU  - Arimura Y
AD  - l Nephrology and Rheumatology, First Department of Internal Medicine , Kyorin 
      University School of Medicine , Mitaka, Tokyo , Japan , and.
FAU - Makino, Hirofumi
AU  - Makino H
AD  - m Okayama University Hospital , Kita-ku, Okayama , Japan.
CN  - Research Committee on Intractable Vasculitides, the Ministry of Health, Labor and 
      Welfare of Japan
LA  - eng
PT  - Journal Article
DEP - 20161010
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*drug therapy
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*adverse effects/therapeutic use
MH  - Incidence
MH  - Infections/*diagnosis/epidemiology/etiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Registries
MH  - Remission Induction
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Antineutrophil cytoplasmic antibody-associated vasculitis
OT  - Corticosteroid
OT  - Inception cohort study
OT  - Risk factors
OT  - Safety
OT  - Serious infection
EDAT- 2016/08/20 06:00
MHDA- 2018/03/27 06:00
CRDT- 2016/08/20 06:00
PHST- 2016/08/20 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2016/08/20 06:00 [entrez]
AID - 10.1080/14397595.2016.1226468 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2017 Jul;27(4):646-651. doi: 10.1080/14397595.2016.1226468. Epub 
      2016 Oct 10.