PMID- 27539303 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240330 IS - 2193-8261 (Print) IS - 2193-6544 (Electronic) IS - 2193-6544 (Linking) VI - 5 IP - 2 DP - 2016 Dec TI - Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors and Cardiovascular Disease: A Systematic Review. PG - 161-168 AB - Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of drugs that have been extensively investigated for the treatment of hyperglycemia in type 2 diabetes mellitus (T2DM). These drugs reduce hyperglycemia by blocking renal glucose reabsorption, thereby promoting increased renal glucose excretion. Beyond glycemic control, these drugs have other beneficial effects on cardiovascular (CV) risk factors. The present review discusses the potential role of SGLT2 inhibitors in treating CV complications (acute and chronic) associated with T2DM. FUNDING: AstraZeneca Pharma India Ltd. FAU - Kalra, Sanjay AU - Kalra S AD - Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India. brideknl@gmail.com. LA - eng PT - Journal Article PT - Review DEP - 20160818 PL - England TA - Cardiol Ther JT - Cardiology and therapy JID - 101634495 EIN - Cardiol Ther. 2016 Dec;5(2):169. PMID: 27620898 PMC - PMC5125111 OTO - NOTNLM OT - Blood pressure OT - Cardiovascular diseases OT - Sodium-glucose cotransporter 2 (SGLT2) inhibitors OT - Treatment EDAT- 2016/08/20 06:00 MHDA- 2016/08/20 06:01 PMCR- 2016/08/18 CRDT- 2016/08/20 06:00 PHST- 2016/06/11 00:00 [received] PHST- 2016/08/20 06:00 [pubmed] PHST- 2016/08/20 06:01 [medline] PHST- 2016/08/20 06:00 [entrez] PHST- 2016/08/18 00:00 [pmc-release] AID - 10.1007/s40119-016-0069-z [pii] AID - 69 [pii] AID - 10.1007/s40119-016-0069-z [doi] PST - ppublish SO - Cardiol Ther. 2016 Dec;5(2):161-168. doi: 10.1007/s40119-016-0069-z. Epub 2016 Aug 18.