PMID- 27540576
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160819
LR  - 20200930
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 4
IP  - 8
DP  - 2016 Aug
TI  - Endoscopic resection is effective for the treatment of bleeding gastric 
      hyperplastic polyps in patients with and without cirrhosis.
PG  - E874-7
LID - 10.1055/s-0042-109773 [doi]
AB  - BACKGROUND AND STUDY AIMS: Gastric hyperplastic polyps (GHP) have been identified 
      as a cause of transfusion-dependent iron-deficiency anemia (tIDA) and 
      transfusion-dependent gastrointestinal bleeding and are commonly identified in 
      the setting of cirrhosis. The aim of this study was to assess the effectiveness 
      of endoscopic resection (ER) for the treatment of tIDA or gastrointestinal 
      bleeding due to GHP in patients with and without liver disease. PATIENTS AND 
      METHODS: This was a single-center retrospective review. The primary outcome was 
      clinical success of ER (no transfusion or repeat ER in the following 6 months 
      after first ER). Secondary outcomes included technical success, recurrence of GHP 
      with tIDA or gastrointestinal bleeding, and adverse events (AEs). RESULTS: 
      Sixty-three patients with GHP were included of whom 20 (31 %) had cirrhosis. The 
      majority with cirrhosis presented with gastrointestinal bleeding (n = 13, 65 %, 
      P = 0.52), whereas the majority of non-cirrhotics presented with tIDA (n = 30, 
      70 %, P = 0.01). Technical success was 100 % with no AEs. The clinical success 
      rate was 94 % (95 % in cirrhotics, 93 % in non-cirrhotics, P = 0.46). The 
      recurrence rate was 32 % (40 % in cirrhotics and 28 % in non-cirrhotics, 
      P = 0.35) with mean time to recurrence of 17.3 +/- 13.9 months (P = 0.22). Of those 
      with recurrence, 75 % had no further tIDA or gastrointestinal bleeding after 
      repeat ER (mean follow-up 20 +/-11 months). CONCLUSIONS: ER is an effective 
      treatment for GHP that causes tIDA or gastrointestinal bleeding. Patients with 
      GHP and cirrhosis tend to present with bleeding rather than anemia and have more 
      frequent recurrence. Symptomatic recurrence of GHP is common and should be 
      recognized early as repeat ER appears to be effective.
FAU - Nelson, Matthew
AU  - Nelson M
AD  - Department of Gastroenterology and Hepatology, Northwestern University, Chicago, 
      Illinois, United States.
FAU - Ganger, Daniel
AU  - Ganger D
AD  - Department of Gastroenterology and Hepatology, Northwestern University, Chicago, 
      Illinois, United States.
FAU - Keswani, Rajesh
AU  - Keswani R
AD  - Department of Gastroenterology and Hepatology, Northwestern University, Chicago, 
      Illinois, United States.
FAU - Grande, David
AU  - Grande D
AD  - Department of Gastroenterology and Hepatology, Northwestern University, Chicago, 
      Illinois, United States.
FAU - Komanduri, Srinadh
AU  - Komanduri S
AD  - Department of Gastroenterology and Hepatology, Northwestern University, Chicago, 
      Illinois, United States.
LA  - eng
GR  - P30 CA060553/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20160808
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC4988837
COIS- Competing interests: None
EDAT- 2016/08/20 06:00
MHDA- 2016/08/20 06:01
PMCR- 2016/08/01
CRDT- 2016/08/20 06:00
PHST- 2015/12/03 00:00 [received]
PHST- 2016/05/30 00:00 [accepted]
PHST- 2016/08/20 06:00 [entrez]
PHST- 2016/08/20 06:00 [pubmed]
PHST- 2016/08/20 06:01 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 10.1055/s-0042-109773 [doi]
PST - ppublish
SO  - Endosc Int Open. 2016 Aug;4(8):E874-7. doi: 10.1055/s-0042-109773. Epub 2016 Aug 
      8.