PMID- 27541731
OWN - NLM
STAT- MEDLINE
DCOM- 20170523
LR  - 20181113
IS  - 1553-7404 (Electronic)
IS  - 1553-7390 (Print)
IS  - 1553-7390 (Linking)
VI  - 12
IP  - 8
DP  - 2016 Aug
TI  - HAPLESS13-Mediated Trafficking of STRUBBELIG Is Critical for Ovule Development in 
      Arabidopsis.
PG  - e1006269
LID - 10.1371/journal.pgen.1006269 [doi]
LID - e1006269
AB  - Planar morphogenesis, a distinct feature of multicellular organisms, is crucial 
      for the development of ovule, progenitor of seeds. Both receptor-like kinases 
      (RLKs) such as STRUBBELIG (SUB) and auxin gradient mediated by PIN-FORMED1 (PIN1) 
      play instructive roles in this process. Fine-tuned intercellular communications 
      between different cell layers during ovule development demands dynamic membrane 
      distribution of these cell-surface proteins, presumably through vesicle-mediated 
      sorting. However, the way it's achieved and the trafficking routes involved are 
      obscure. We report that HAPLESS13 (HAP13)-mediated trafficking of SUB is critical 
      for ovule development. HAP13 encodes the mu subunit of adaptor protein 1 (AP1) 
      that mediates protein sorting at the trans-Golgi network/early endosome (TGN/EE). 
      The HAP13 mutant, hap13-1, is defective in outer integument growth, resulting in 
      exposed nucellus accompanied with impaired pollen tube guidance and reception. 
      SUB is mis-targeted in hap13-1. However, unlike that of PIN2, the distribution of 
      PIN1 is independent of HAP13. Genetic interference of exocytic trafficking at the 
      TGN/EE by specifically downregulating HAP13 phenocopied the defects of hap13-1 in 
      SUB targeting and ovule development, supporting a key role of sporophytically 
      expressed SUB in instructing female gametogenesis.
FAU - Wang, Jia-Gang
AU  - Wang JG
AD  - State Key Laboratory of Crop Biology, College of Life Sciences, Shandong 
      Agricultural University, Tai'an, China.
FAU - Feng, Chong
AU  - Feng C
AD  - State Key Laboratory of Crop Biology, College of Life Sciences, Shandong 
      Agricultural University, Tai'an, China.
FAU - Liu, Hai-Hong
AU  - Liu HH
AD  - State Key Laboratory of Crop Biology, College of Life Sciences, Shandong 
      Agricultural University, Tai'an, China.
FAU - Ge, Fu-Rong
AU  - Ge FR
AD  - State Key Laboratory of Crop Biology, College of Life Sciences, Shandong 
      Agricultural University, Tai'an, China.
FAU - Li, Sha
AU  - Li S
AD  - State Key Laboratory of Crop Biology, College of Life Sciences, Shandong 
      Agricultural University, Tai'an, China.
FAU - Li, Hong-Ju
AU  - Li HJ
AUID- ORCID: 0000-0003-0064-4626
AD  - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics 
      and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - State Key Laboratory of Crop Biology, College of Life Sciences, Shandong 
      Agricultural University, Tai'an, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160819
PL  - United States
TA  - PLoS Genet
JT  - PLoS genetics
JID - 101239074
RN  - 0 (AP1 protein, Arabidopsis)
RN  - 0 (AP1M2 protein, Arabidopsis)
RN  - 0 (Adaptor Protein Complex 1)
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Indoleacetic Acids)
RN  - 0 (MADS Domain Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (PIN1 protein, Arabidopsis)
RN  - 0 (PIN2 protein, Arabidopsis)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (SUB protein, Arabidopsis)
SB  - IM
MH  - Adaptor Protein Complex 1/*genetics
MH  - Arabidopsis/genetics/growth & development
MH  - Arabidopsis Proteins/biosynthesis/*genetics
MH  - Endosomes/genetics
MH  - Gametogenesis, Plant/genetics
MH  - Gene Expression Regulation, Plant
MH  - Indoleacetic Acids/metabolism
MH  - MADS Domain Proteins/biosynthesis/genetics
MH  - Membrane Transport Proteins/biosynthesis/*genetics
MH  - Ovule/*genetics/growth & development
MH  - Plant Development/genetics
MH  - Protein Transport/genetics
MH  - Receptor Protein-Tyrosine Kinases/biosynthesis/*genetics
MH  - Signal Transduction
PMC - PMC4991792
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/08/20 06:00
MHDA- 2017/05/24 06:00
PMCR- 2016/08/19
CRDT- 2016/08/20 06:00
PHST- 2016/03/25 00:00 [received]
PHST- 2016/07/30 00:00 [accepted]
PHST- 2016/08/20 06:00 [entrez]
PHST- 2016/08/20 06:00 [pubmed]
PHST- 2017/05/24 06:00 [medline]
PHST- 2016/08/19 00:00 [pmc-release]
AID - PGENETICS-D-16-00690 [pii]
AID - 10.1371/journal.pgen.1006269 [doi]
PST - epublish
SO  - PLoS Genet. 2016 Aug 19;12(8):e1006269. doi: 10.1371/journal.pgen.1006269. 
      eCollection 2016 Aug.