PMID- 27543510
OWN - NLM
STAT- MEDLINE
DCOM- 20170419
LR  - 20170419
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 25
IP  - 1
DP  - 2017 Feb
TI  - Circulating Breast Carcinoma Cells Mimicking Therapy-Related Acute Myeloid 
      Leukemia.
PG  - 87-93
LID - 10.1177/1066896916664986 [doi]
AB  - Circulating tumor cells are rare in peripheral blood smears. We report the case 
      of a patient with circulating breast carcinoma cells resembling circulating 
      myeloid blasts and provide a brief review of the literature. Peripheral blood 
      smears and a bone marrow aspirate were examined morphologically and by flow 
      cytometry and fluorescence in situ hybridization (FISH). Bone marrow histology in 
      conjunction with immunohistochemical stains was also evaluated. A population of 
      atypical cells with blast-like morphology was present in the peripheral blood. 
      Flow cytometry showed a 9% population of CD45 dim positive, CD13 partial 
      positive, and CD15 variably positive cells. Peripheral blood FISH analysis 
      revealed deletion 7q, gain of 8q, and deletions 16q and 17q in 32.5% to 36% of 
      200 interphase cells analyzed. The bone marrow biopsy showed cohesive groups of 
      cytokeratin AE1/AE3 positive cells. Our report demonstrates that circulating 
      carcinoma cells can mimic a high-grade myeloid neoplasm morphologically and by 
      flow cytometry and FISH analysis.
FAU - Rowan, Daniel J
AU  - Rowan DJ
AD  - 1 Medical College of Wisconsin, Milwaukee WI, USA.
FAU - Logunova, Valentina
AU  - Logunova V
AD  - 1 Medical College of Wisconsin, Milwaukee WI, USA.
FAU - van Tuinen, Peter
AU  - van Tuinen P
AD  - 1 Medical College of Wisconsin, Milwaukee WI, USA.
FAU - Olteanu, Horatiu
AU  - Olteanu H
AD  - 1 Medical College of Wisconsin, Milwaukee WI, USA.
FAU - Peterson, Jess F
AU  - Peterson JF
AD  - 1 Medical College of Wisconsin, Milwaukee WI, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160820
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Breast Neoplasms/*pathology
MH  - Carcinoma, Ductal, Breast/*pathology
MH  - *Diagnosis, Differential
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*diagnosis/pathology
MH  - Middle Aged
MH  - Neoplastic Cells, Circulating/*pathology
OTO - NOTNLM
OT  - FISH
OT  - acute leukemia
OT  - carcinoma
OT  - cytogenetics
OT  - flow cytometry
EDAT- 2016/08/21 06:00
MHDA- 2017/04/20 06:00
CRDT- 2016/08/21 06:00
PHST- 2016/08/21 06:00 [pubmed]
PHST- 2017/04/20 06:00 [medline]
PHST- 2016/08/21 06:00 [entrez]
AID - 1066896916664986 [pii]
AID - 10.1177/1066896916664986 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2017 Feb;25(1):87-93. doi: 10.1177/1066896916664986. Epub 2016 
      Aug 20.