PMID- 27543676
OWN - NLM
STAT- MEDLINE
DCOM- 20171103
LR  - 20180917
IS  - 0304-4165 (Print)
IS  - 0304-4165 (Linking)
VI  - 1861
IP  - 1 Pt A
DP  - 2017 Jan
TI  - Toll-like receptor-mediated involvement of innate immune cells in asthma disease.
PG  - 3270-3277
LID - S0304-4165(16)30290-2 [pii]
LID - 10.1016/j.bbagen.2016.08.009 [doi]
AB  - BACKGROUND: Innate immune cells as the first line of defense are adept at 
      recognizing and triggering appropriate response against various pathogens. Apart 
      from the protective functions, the innate immunity plays an essential role in 
      mediation of allergic responses. Dendritic cells (DCs) and airway epithelial 
      cells (AECs) along with other innate cells such as granulocytes, natural killer 
      cells (NKs), natural killer T cells (NKTs), and alternatively activated 
      macrophages (AAMs) are able to orchestrate allergic responses, especially asthma. 
      Chronic stimulation of TLRs by airway stimuli induces local inflammation which 
      gradually results in the recruitment and settling of innate cells around airways. 
      SCOPE OF REVIEW: This review discusses how recruitment and accumulation of the 
      inflammatory cells in the site of insult facilitate hypersensitivity reactions 
      and initiate airway inflammation. We indicate that these cells are well equipped 
      to highly sensitive receptors known as toll-like receptors (TLRs) making them fit 
      to prime adaptive immune response. Based on emerging findings, we highlight the 
      pivotal role of TLRs in regulation of innate cells function in the context of 
      asthma disease. MAJOR CONCLUSIONS: Stimulation of the TLRs of innate cells by 
      allergens has been found to accelerate and regulate allergic airway inflammation. 
      In fact, the sophisticated interaction between environmental allergens and TLRs 
      leads to release of various pro-inflammatory mediators from innate cells 
      supporting asthma development. GENERAL SIGNIFICANCE: This review highlights that 
      TLRs have a substantial role in priming innate cells and cytokine release, 
      suggesting that the involvement of TLRs of innate immune cells can modulate the 
      function of these cells in asthma disease.
CI  - Copyright A(c) 2016 Elsevier B.V. All rights reserved.
FAU - Zakeri, Amin
AU  - Zakeri A
AD  - Immunology Section, Department of Pathobiology, Faculty of Veterinary Medicine, 
      Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address: 
      Amin.zakeri@stu-mail.um.ac.ir.
FAU - Yazdi, Fariba Ghiamati
AU  - Yazdi FG
AD  - Department of Food Science and Technology, Faculty of Agriculture, Isfahan 
      University of Technology, Isfahan 84156, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160817
PL  - Netherlands
TA  - Biochim Biophys Acta Gen Subj
JT  - Biochimica et biophysica acta. General subjects
JID - 101731726
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Asthma/*immunology
MH  - Cell Communication
MH  - Humans
MH  - *Immunity, Innate
MH  - Models, Biological
MH  - Th2 Cells/immunology
MH  - Toll-Like Receptors/*metabolism
OTO - NOTNLM
OT  - Allergen
OT  - Asthma
OT  - Innate immune cells
OT  - Toll-like receptors (TLRs)
EDAT- 2016/08/21 06:00
MHDA- 2017/11/04 06:00
CRDT- 2016/08/21 06:00
PHST- 2016/06/08 00:00 [received]
PHST- 2016/08/15 00:00 [accepted]
PHST- 2016/08/21 06:00 [pubmed]
PHST- 2017/11/04 06:00 [medline]
PHST- 2016/08/21 06:00 [entrez]
AID - S0304-4165(16)30290-2 [pii]
AID - 10.1016/j.bbagen.2016.08.009 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3270-3277. doi: 
      10.1016/j.bbagen.2016.08.009. Epub 2016 Aug 17.