PMID- 27543801
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20230411
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 5
IP  - 8
DP  - 2016 Aug 20
TI  - Different Combinations of Glucose Tolerance and Blood Pressure Status and 
      Incident Diabetes, Hypertension, and Chronic Kidney Disease.
LID - 10.1161/JAHA.116.003917 [doi]
LID - e003917
AB  - BACKGROUND: The impact of different combinations of glucose tolerance and blood 
      pressure status on the development of type 2 diabetes mellitus (T2DM), 
      hypertension (HTN), and chronic kidney disease (CKD) still needs to be 
      investigated. METHODS AND RESULTS: A total of 12 808 Iranian adults aged 
      >/=20 years were included in 3 separate analyses to investigate incidence of T2DM, 
      HTN, and CKD. Multivariate Cox proportional hazard models were used to calculate 
      hazard ratios (95% CI). During a median follow-up of >10 years, the overall 
      incidence rate for T2DM, HTN, and CKD was 12.2, 29.8, and 24.8 per 
      1000 person-years. For incident T2DM, considering normal glucose tolerance/normal 
      blood pressure as reference, prediabetes (PreDM)/HTN had the highest risk (hazard 
      ratio: 7.22 [5.71-9.12]) while PreDM/normal blood pressure also showed a 
      significant risk (5.58 [4.41-7.05]). Furthermore, risk of PreDM/HTN was higher 
      than PreDM/normal blood pressure (P<0.05). For incident HTN, normal glucose 
      tolerance/prehypertension was a strong predictor (3.28 [2.91-3.69]); however, 
      addition of PreDM or T2DM did not increase the risk. For incident CKD, every 
      category that included HTN and/or T2DM showed significant risk; this risk was 
      marginally significant for the PreDM/HTN group (1.19 [0.98-1.43], P=0.06). In 
      addition, PreDM/ normal blood pressure was a marginally significant risk factor 
      for incident HTN while normal glucose tolerance/prehypertension was a significant 
      predictor of T2DM. CONCLUSIONS: Presence of HTN was associated with increased 
      risk of T2DM among the PreDM population; however, dysglycemia did not increase 
      the risk of HTN among individuals with prehypertension. For incident CKD, 
      intensive management of HTN and T2DM, rather than their predisease states, should 
      be considered.
CI  - (c) 2016 The Authors. Published on behalf of the American Heart Association, Inc., 
      by Wiley Blackwell.
FAU - Derakhshan, Arash
AU  - Derakhshan A
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Bagherzadeh-Khiabani, Farideh
AU  - Bagherzadeh-Khiabani F
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Arshi, Banafsheh
AU  - Arshi B
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Ramezankhani, Azra
AU  - Ramezankhani A
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Azizi, Fereidoun
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Hadaegh, Farzad
AU  - Hadaegh F
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 
      fzhadaegh@endocrine.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160820
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/physiology
MH  - Diabetes Mellitus, Type 2/epidemiology/*etiology
MH  - Diabetic Angiopathies/epidemiology/*etiology
MH  - Diabetic Nephropathies/epidemiology/*etiology
MH  - Female
MH  - Glucose Intolerance/epidemiology/etiology
MH  - Humans
MH  - Hypertension/*complications/epidemiology
MH  - Incidence
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/epidemiology/etiology
MH  - Prehypertension/complications/epidemiology
MH  - Prospective Studies
MH  - Renal Insufficiency, Chronic/epidemiology/*etiology
MH  - Risk Factors
PMC - PMC5015306
OTO - NOTNLM
OT  - blood pressure
OT  - chronic kidney disease
OT  - diabetes
OT  - glucose tolerance
OT  - hypertension
OT  - prediabetes
OT  - prehypertension
EDAT- 2016/08/21 06:00
MHDA- 2018/01/10 06:00
PMCR- 2016/08/01
CRDT- 2016/08/21 06:00
PHST- 2016/08/21 06:00 [entrez]
PHST- 2016/08/21 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - JAHA.116.003917 [pii]
AID - JAH31712 [pii]
AID - 10.1161/JAHA.116.003917 [doi]
PST - epublish
SO  - J Am Heart Assoc. 2016 Aug 20;5(8):e003917. doi: 10.1161/JAHA.116.003917.