PMID- 27545218
OWN - NLM
STAT- MEDLINE
DCOM- 20170130
LR  - 20220317
IS  - 1881-7823 (Electronic)
IS  - 1881-7815 (Linking)
VI  - 10
IP  - 5
DP  - 2016 Nov 15
TI  - MicroRNA-613 regulates the expression of brain-derived neurotrophic factor in 
      Alzheimer's disease.
PG  - 372-377
AB  - Alzheimer's disease (AD) is a neurodegenerative disorder characterized by 
      progressive loss of memory and other cognitive functions and presents an 
      increasing clinical challenge in terms of diagnosis and treatment. Brain-derived 
      neurotrophic factor (BDNF) plays an important role in neuronal survival and 
      proliferation. In the present study, the mRNA and protein expression level of 
      BDNF was detected in serum, and cerebrospinal fluid (CSF) of patients with mild 
      cognitive impairment (MCI), dementia of Alzheimer's type (DAT), and hippocampus 
      in APP/PS1 mice. A significant decrease of BDNF mRNA and protein expression was 
      observed in serum and CSF of patients and hippocampus in APP/PS1 mice compared 
      with the corresponding controls. miR-613, which is predicted to target the 3'-UTR 
      of BDNF, was also detected in patients and the mouse model. Opposite to the 
      alteration of BDNF, miR-613 expression in serum, CSF and hippocampus were 
      obviously increased compared to the controls. In conclusion, these findings 
      showed that miR-613 may function in the development of AD and may provide new 
      insights in diagnosis and treatment of AD.
FAU - Li, Wei
AU  - Li W
AD  - Department of Clinical Laboratory, Tianjin Huan Hu Hospital.
FAU - Li, Xu
AU  - Li X
FAU - Xin, Xin
AU  - Xin X
FAU - Kan, Peng-Cheng
AU  - Kan PC
FAU - Yan, Yan
AU  - Yan Y
LA  - eng
PT  - Journal Article
DEP - 20160819
PL  - Japan
TA  - Biosci Trends
JT  - Bioscience trends
JID - 101502754
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MicroRNAs)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Aged
MH  - Alzheimer Disease/genetics/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cell Line
MH  - Cognitive Dysfunction/genetics/metabolism
MH  - Female
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - MicroRNAs/genetics/*metabolism
MH  - Middle Aged
EDAT- 2016/08/23 06:00
MHDA- 2017/01/31 06:00
CRDT- 2016/08/23 06:00
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/01/31 06:00 [medline]
PHST- 2016/08/23 06:00 [entrez]
AID - 10.5582/bst.2016.01127 [doi]
PST - ppublish
SO  - Biosci Trends. 2016 Nov 15;10(5):372-377. doi: 10.5582/bst.2016.01127. Epub 2016 
      Aug 19.