PMID- 27545493
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20180403
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 76
IP  - 4
DP  - 2016 Oct
TI  - Association of peripheral blood dendritic cells with recurrent pregnancy loss: a 
      case-controlled study.
PG  - 326-32
LID - 10.1111/aji.12550 [doi]
AB  - PROBLEM: Dendritic cells (DCs) have been reported to play an important role in 
      pregnancy. However, the role of DCs in recurrent pregnancy loss (RPL) has not 
      been investigated well. METHOD OF STUDY: Forty-three women affected by RPL and 16 
      fertile controls were recruited from June 2013 to December 2014. The peripheral 
      blood DCs subsets, including myeloid DCs (mDCs) and plasmacytoid DCs (pDCs), the 
      levels (%) of CD80(+) , CD86(+) , and CD200(+) DCs were analyzed using flow 
      cytometry. RESULTS: The levels of total DCs, mDCs, and CD86(+) DCs were 
      significantly higher (all P<.05); however, the level of CD200(+) DCs in the RPL 
      group was significantly lower than that of the control group (P<.05). The 
      logistical regression analyses showed that the elevated level of mDCs was 
      significantly associated with RPL after adjustment for age (OR: 1.14, 95% CI, 
      1.01-1.29, P<.05). CONCLUSION: The elevated level of mDCs was significantly 
      associated with RPL, which might lead to the intervention of targeted 
      immunosuppression in women with RPL.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Huang, Chunyu
AU  - Huang C
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
AD  - Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, 
      China.
FAU - Zhang, Hongzhan
AU  - Zhang H
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
AD  - Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing 
      Medical University, Chongqing, China.
FAU - Chen, Xian
AU  - Chen X
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
AD  - Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, 
      China.
FAU - Diao, Lianghui
AU  - Diao L
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
AD  - Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, 
      China.
FAU - Lian, Ruochun
AU  - Lian R
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
AD  - Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, 
      China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
AD  - Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, 
      China.
FAU - Hu, Lina
AU  - Hu L
AD  - Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing 
      Medical University, Chongqing, China. cqhulina@126.com.
FAU - Zeng, Yong
AU  - Zeng Y
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China. 
      zengyong1966@gmail.com.
AD  - Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, 
      China. zengyong1966@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160821
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Abortion, Habitual/*immunology
MH  - Adult
MH  - Antigens, CD/metabolism
MH  - Blood Cells/*immunology
MH  - Case-Control Studies
MH  - Cell Separation
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Myeloid Cells/*immunology
MH  - Pregnancy
OTO - NOTNLM
OT  - CD200
OT  - case-controlled study
OT  - co-stimulatory molecules
OT  - dendritic cells
OT  - recurrent pregnancy loss
EDAT- 2016/08/23 06:00
MHDA- 2017/12/27 06:00
CRDT- 2016/08/23 06:00
PHST- 2016/06/18 00:00 [received]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 10.1111/aji.12550 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2016 Oct;76(4):326-32. doi: 10.1111/aji.12550. Epub 2016 Aug 
      21.