PMID- 27545969
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20190417
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 7
DP  - 2016 Aug 22
TI  - Characterization of a recently evolved flavonol-phenylacyltransferase gene 
      provides signatures of natural light selection in Brassicaceae.
PG  - 12399
LID - 10.1038/ncomms12399 [doi]
LID - 12399
AB  - Incidence of natural light stress renders it important to enhance our 
      understanding of the mechanisms by which plants protect themselves from harmful 
      effects of UV-B irradiation, as this is critical for fitness of land plant 
      species. Here we describe natural variation of a class of 
      phenylacylated-flavonols (saiginols), which accumulate to high levels in floral 
      tissues of Arabidopsis. They were identified in a subset of accessions, 
      especially those deriving from latitudes between 16 degrees  and 43 degrees  North. Investigation 
      of introgression line populations using metabolic and transcript profiling, 
      combined with genomic sequence analysis, allowed the identification of 
      flavonol-phenylacyltransferase 2 (FPT2) that is responsible for the production of 
      saiginols and conferring greater UV light tolerance in planta. Furthermore, 
      analysis of polymorphism within the FPT duplicated region provides an 
      evolutionary framework of the natural history of this locus in the Brassicaceae.
FAU - Tohge, Takayuki
AU  - Tohge T
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
FAU - Wendenburg, Regina
AU  - Wendenburg R
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
FAU - Ishihara, Hirofumi
AU  - Ishihara H
AUID- ORCID: 0000-0002-7658-0473
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
FAU - Nakabayashi, Ryo
AU  - Nakabayashi R
AD  - Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1 
      Chuo-ku, Chiba 260-8675, Japan.
FAU - Watanabe, Mutsumi
AU  - Watanabe M
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
FAU - Sulpice, Ronan
AU  - Sulpice R
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
FAU - Hoefgen, Rainer
AU  - Hoefgen R
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
FAU - Takayama, Hiromitsu
AU  - Takayama H
AD  - Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1 
      Chuo-ku, Chiba 260-8675, Japan.
FAU - Saito, Kazuki
AU  - Saito K
AD  - Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1 
      Chuo-ku, Chiba 260-8675, Japan.
AD  - RIKEN Center for Sustainable Resource Science, Suehiro-cho 1-7-22, Yokohama 
      230-0045, Japan.
FAU - Stitt, Mark
AU  - Stitt M
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
FAU - Fernie, Alisdair R
AU  - Fernie AR
AD  - Max-Planck-Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 
      Potsdam-Golm, Germany.
AD  - Center of Plant System Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160822
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Flavonols)
RN  - 0 (Protein Isoforms)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (FTP2 protein, Arabidopsis)
SB  - IM
MH  - Acyltransferases/*physiology
MH  - Alternative Splicing
MH  - Arabidopsis/*physiology/radiation effects
MH  - Arabidopsis Proteins/*physiology
MH  - Flavonols/metabolism
MH  - Flowers/metabolism
MH  - Gene Duplication/physiology
MH  - Gene Expression Regulation, Plant/*radiation effects
MH  - Genes, Plant/*physiology
MH  - Polymorphism, Genetic
MH  - Protein Isoforms/physiology
MH  - Selection, Genetic/*physiology
MH  - Ultraviolet Rays/adverse effects
PMC - PMC4996938
COIS- T.T., R.W., H.I., R.S., M.S. and A.R.F. have filed patent applications on 
      saiginol derivatives and FPT gene function. The remaining authors declare no 
      competing financial interests.
EDAT- 2016/08/23 06:00
MHDA- 2018/09/05 06:00
PMCR- 2016/08/22
CRDT- 2016/08/23 06:00
PHST- 2015/09/07 00:00 [received]
PHST- 2016/06/29 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2016/08/22 00:00 [pmc-release]
AID - ncomms12399 [pii]
AID - 10.1038/ncomms12399 [doi]
PST - epublish
SO  - Nat Commun. 2016 Aug 22;7:12399. doi: 10.1038/ncomms12399.