PMID- 27546026
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20170207
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 95
IP  - 11
DP  - 2016 Oct
TI  - Abnormal expression of inflammatory genes in placentas of women with sickle cell 
      anemia and sickle hemoglobin C disease.
PG  - 1859-67
LID - 10.1007/s00277-016-2780-1 [doi]
AB  - Sickle cell disease (SCD) is a complex disease that is characterized by the 
      polymerization of deoxyhemoglobin S, altered red blood cell membrane biology, 
      endothelial activation, hemolysis, a procoagulant state, acute and chronic 
      inflammation, and vaso-occlusion. Among the physiological changes that occur 
      during pregnancy, oxygen is consumed by fetal growth, and pregnant women with SCD 
      are more frequently exposed to low oxygen levels. This might lead to red blood 
      cells sickling, and, consequently, to vaso-occlusion. The mechanisms by which SCD 
      affects placental physiology are largely unknown, and chronic inflammation might 
      be involved in this process. This study aimed to evaluate the gene expression 
      profile of inflammatory response mediators in the placentas of pregnant women 
      with sickle cell cell anemia (HbSS) and hemoglobinopathy SC (HbSC). Our results 
      show differences in a number of these genes. For the HbSS group, when compared to 
      the control group, the following genes showed differential expression: IL1RAP 
      (2.76-fold), BCL6 (4.49-fold), CXCL10 (-2.12-fold), CXCR1 (-3.66-fold), and C3 
      (-2.0-fold). On the other hand, the HbSC group presented differential expressions 
      of the following genes, when compared to the control group: IL1RAP (4.33-fold), 
      CXCL1 (3.05-fold), BCL6 (4.13-fold), CXCL10 (-3.32-fold), C3 (-2.0-fold), and 
      TLR3 (2.38-fold). Taken together, these data strongly suggest a differential 
      expression of several inflammatory genes in both SCD (HbSS and HbSC), indicating 
      that the placenta might become an environment with hypoxia, and increased 
      inflammation, which could lead to improper placental development.
FAU - Baptista, Leticia C
AU  - Baptista LC
AD  - Center for Molecular Biology and Genetic Engineering (CBMEG), University of 
      Campinas - UNICAMP, Campinas, SP, Brazil.
FAU - Costa, Maria Laura
AU  - Costa ML
AD  - Department of Obstetrics and Gynecology, University of Campinas - UNICAMP, School 
      of Medicine, Campinas, Sao Paulo, Brazil.
FAU - Ferreira, Regiane
AU  - Ferreira R
AD  - Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, 
      Sao Paulo, Brazil.
FAU - Albuquerque, Dulcineia M
AU  - Albuquerque DM
AD  - Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, 
      Sao Paulo, Brazil.
FAU - Lanaro, Carolina
AU  - Lanaro C
AD  - Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, 
      Sao Paulo, Brazil.
FAU - Fertrin, Kleber Y
AU  - Fertrin KY
AD  - Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, 
      Sao Paulo, Brazil.
FAU - Surita, Fernanda G
AU  - Surita FG
AD  - Department of Obstetrics and Gynecology, University of Campinas - UNICAMP, School 
      of Medicine, Campinas, Sao Paulo, Brazil.
FAU - Parpinelli, Mary A
AU  - Parpinelli MA
AD  - Department of Obstetrics and Gynecology, University of Campinas - UNICAMP, School 
      of Medicine, Campinas, Sao Paulo, Brazil.
FAU - Costa, Fernando F
AU  - Costa FF
AD  - Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, 
      Sao Paulo, Brazil.
FAU - Melo, Monica Barbosa de
AU  - Melo MB
AD  - Center for Molecular Biology and Genetic Engineering (CBMEG), University of 
      Campinas - UNICAMP, Campinas, SP, Brazil. melomb@uol.com.br.
AD  - Laboratory of Human Genetics, Center for Molecular Biology and Genetic 
      Engineering (CBMEG), University of Campinas - UNICAMP, P.O. Box: 6010, Campinas, 
      SP, 13083-875, Brazil. melomb@uol.com.br.
LA  - eng
PT  - Journal Article
DEP - 20160822
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Cytokine)
SB  - IM
MH  - Adult
MH  - Anemia, Sickle Cell/complications/*genetics
MH  - Case-Control Studies
MH  - Cytokines/*biosynthesis/genetics
MH  - Female
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - Hemoglobin SC Disease/complications/*genetics
MH  - Humans
MH  - Inflammation/etiology/*genetics
MH  - Placenta/*metabolism/pathology
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Cytokine/*biosynthesis/genetics
MH  - Reproductive History
MH  - Young Adult
OTO - NOTNLM
OT  - Gene expression
OT  - Inflammation
OT  - Placenta
OT  - Pregnancy
OT  - Sickle cell disease
EDAT- 2016/08/23 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/08/23 06:00
PHST- 2016/06/27 00:00 [received]
PHST- 2016/08/01 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 10.1007/s00277-016-2780-1 [pii]
AID - 10.1007/s00277-016-2780-1 [doi]
PST - ppublish
SO  - Ann Hematol. 2016 Oct;95(11):1859-67. doi: 10.1007/s00277-016-2780-1. Epub 2016 
      Aug 22.