PMID- 27546908
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0026-9247 (Print)
IS  - 1434-4475 (Electronic)
IS  - 0026-9247 (Linking)
VI  - 147
DP  - 2016
TI  - The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive 
      substances in hair samples and several "legal highs" products.
PG  - 1407-1414
AB  - ABSTRACT: Non-targeted screening of drugs present in herbal products, known as 
      "legal high" drugs and in hair as a biological matrix commonly used in 
      toxicological investigations was accomplished with the use of high pressure 
      liquid chromatography coupled with quadrupole time-of-flight mass spectrometry 
      (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive 
      substances/metabolites were detected in investigated hair samples and herbal 
      products, respectively. We demonstrate that the HPLC-Q-TOF methodology seems to 
      be a powerful tool in the qualitative analysis applied in identification of these 
      designer drugs, thus enabling a laboratory to stay-up-to-date with the drugs that 
      are being sold as legal high products on black market.
FAU - Aszyk, Justyna
AU  - Aszyk J
AD  - Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of 
      Technology, Gdansk, Poland.
FAU - Kot-Wasik, Agata
AU  - Kot-Wasik A
AD  - Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of 
      Technology, Gdansk, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160607
PL  - Austria
TA  - Monatsh Chem
JT  - Monatshefte fur chemie
JID - 0254164
PMC - PMC4971043
OTO - NOTNLM
OT  - Drug research
OT  - Extraction
OT  - Mass spectroscopy
OT  - Quadrupole time-of-flight mass analyzer
EDAT- 2016/08/23 06:00
MHDA- 2016/08/23 06:01
PMCR- 2016/06/07
CRDT- 2016/08/23 06:00
PHST- 2016/01/31 00:00 [received]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2016/08/23 06:01 [medline]
PHST- 2016/06/07 00:00 [pmc-release]
AID - 1773 [pii]
AID - 10.1007/s00706-016-1773-z [doi]
PST - ppublish
SO  - Monatsh Chem. 2016;147:1407-1414. doi: 10.1007/s00706-016-1773-z. Epub 2016 Jun 
      7.