PMID- 27546995
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20201209
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2016
DP  - 2016
TI  - Association of Serum Adropin Concentrations with Diabetic Nephropathy.
PG  - 6038261
LID - 10.1155/2016/6038261 [doi]
LID - 6038261
AB  - Objective. Adropin is a newly identified regulatory protein encoded by the Enho 
      gene and is critically involved in energy homeostasis and insulin sensitivity. 
      This study aims to determine the correlation of serum adropin concentrations with 
      diabetic nephropathy (DN). Methods. This study consisted of 245 patients with 
      type 2 diabetes mellitus (T2DM) and 81 healthy subjects. Then T2DM patients were 
      divided into normoalbuminuria, microalbuminuria, and macroalbuminuria subgroups 
      based on urine albumin to creatinine ratio (ACR). Results. T2DM patients showed 
      significantly lower serum adropin concentrations than those in the controls. T2DM 
      patients with macroalbuminuria had significantly decreased serum adropin 
      concentrations compared with the other three groups. In addition, T2DM patients 
      with microalbuminuria showed lower serum adropin concentrations than those in 
      patients with normoalbuminuria. Logistic regression analysis showed that serum 
      adropin was correlated with decreased risk of developing T2DM and DN. Pearson 
      correlation analysis indicated that serum adropin was negatively correlated with 
      body mass index (BMI), blood urea nitrogen, creatinine, and ACR and positively 
      correlated with glomerular filtration rate. Furthermore, multiple linear 
      regression analysis showed that BMI and ACR were negatively correlated with serum 
      adropin levels. Conclusion. Serum adropin concentrations are negatively 
      associated with renal function. Adropin may be implicated in the pathogenesis of 
      DN development.
FAU - Hu, Wenchao
AU  - Hu W
AUID- ORCID: 0000-0003-0230-1264
AD  - Department of Endocrinology, Qilu Hospital, Shandong University, Qingdao, China.
FAU - Chen, Li
AU  - Chen L
AUID- ORCID: 0000-0001-7670-8062
AD  - Department of Endocrinology, Qilu Hospital, Shandong University, 107 West Wenhua 
      Road, Jinan, Shandong 250012, China.
LA  - eng
PT  - Journal Article
DEP - 20160728
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Blood Proteins)
RN  - 0 (Enho protein, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Peptides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/blood
MH  - Blood Proteins/*chemistry
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood
MH  - Diabetic Nephropathies/*blood
MH  - Female
MH  - Glomerular Filtration Rate/physiology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Peptides/*chemistry
MH  - Risk Factors
PMC - PMC4980507
EDAT- 2016/08/23 06:00
MHDA- 2017/05/16 06:00
PMCR- 2016/07/28
CRDT- 2016/08/23 06:00
PHST- 2016/04/27 00:00 [received]
PHST- 2016/06/26 00:00 [revised]
PHST- 2016/06/29 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/07/28 00:00 [pmc-release]
AID - 10.1155/2016/6038261 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2016;2016:6038261. doi: 10.1155/2016/6038261. Epub 2016 Jul 
      28.