PMID- 27547493
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 2161-1653 (Print)
IS  - 2161-1653 (Electronic)
IS  - 2161-1653 (Linking)
VI  - 5
IP  - 8
DP  - 2016 Aug 16
TI  - Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug.
PG  - 936-941
AB  - We introduce the use of block copolymer membranes for an emerging application, 
      "drug capture". The polymer is incorporated in a new class of biomedical devices, 
      referred to as ChemoFilter, which is an image-guided temporarily deployable 
      endovascular device designed to increase the efficacy of chemotherapy-based 
      cancer treatment. We show that block copolymer membranes consisting of functional 
      sulfonated polystyrene end blocks and a structural polyethylene middle block 
      (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on 
      the relationship between morphology of the membrane in the ChemoFilter device and 
      efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray 
      scattering and cryogenic scanning transmission electron microscopy, we discovered 
      that rapid doxorubicin capture is associated with the presence of water-rich 
      channels in the lamellar-forming S-SES membranes in aqueous environment.
FAU - Chen, X Chelsea
AU  - Chen XC
AD  - Materials Sciences Division and Energy Technologies Area, Lawrence Berkeley 
      National Laboratory, Berkeley, California 94720, United States; Department of 
      Chemical and Biomolecular Engineering, University of California-Berkeley, 
      Berkeley, California 94720, United States.
FAU - Oh, Hee Jeung
AU  - Oh HJ
AD  - Department of Chemical and Biomolecular Engineering, University of 
      California-Berkeley , Berkeley, California 94720, United States.
FAU - Yu, Jay F
AU  - Yu JF
AD  - Department of Radiology and Biomedical Imaging, University of California-San 
      Francisco , San Francisco, California 94107, United States.
FAU - Yang, Jeffrey K
AU  - Yang JK
AD  - Department of Radiology and Biomedical Imaging, University of California-San 
      Francisco , San Francisco, California 94107, United States.
FAU - Petzetakis, Nikos
AU  - Petzetakis N
AD  - Department of Chemical and Biomolecular Engineering, University of 
      California-Berkeley , Berkeley, California 94720, United States.
FAU - Patel, Anand S
AU  - Patel AS
AD  - Department of Radiology and Biomedical Imaging, University of California-San 
      Francisco , San Francisco, California 94107, United States.
FAU - Hetts, Steven W
AU  - Hetts SW
AD  - Department of Radiology and Biomedical Imaging, University of California-San 
      Francisco , San Francisco, California 94107, United States.
FAU - Balsara, Nitash P
AU  - Balsara NP
AD  - Materials Sciences Division and Energy Technologies Area, Lawrence Berkeley 
      National Laboratory, Berkeley, California 94720, United States; Department of 
      Chemical and Biomolecular Engineering, University of California-Berkeley, 
      Berkeley, California 94720, United States; Materials Sciences Division and Energy 
      Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, California 
      94720, United States.
LA  - eng
GR  - R01 CA194533/CA/NCI NIH HHS/United States
GR  - R41 CA183327/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20160723
PL  - United States
TA  - ACS Macro Lett
JT  - ACS macro letters
JID - 101574672
PMC - PMC4989249
COIS- The authors declare no competing financial interest.
EDAT- 2016/08/23 06:00
MHDA- 2016/08/23 06:01
PMCR- 2016/08/18
CRDT- 2016/08/23 06:00
PHST- 2016/06/15 00:00 [received]
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2016/08/23 06:01 [medline]
PHST- 2016/08/18 00:00 [pmc-release]
AID - 10.1021/acsmacrolett.6b00459 [doi]
PST - ppublish
SO  - ACS Macro Lett. 2016 Aug 16;5(8):936-941. doi: 10.1021/acsmacrolett.6b00459. Epub 
      2016 Jul 23.