PMID- 27547764
OWN - NLM
STAT- MEDLINE
DCOM- 20170609
LR  - 20220408
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus.
PG  - 2902351
LID - 10.1155/2016/2902351 [doi]
LID - 2902351
AB  - Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, which by all predictions 
      will only increase. To help in combating the devastating array of phenotypes 
      associated with T2DM a highly reproducible and human disease-similar mouse model 
      is required for researchers. The current options are genetic manipulations to 
      cause T2DM symptoms or diet induced obesity and T2DM symptoms. These methods to 
      model human T2DM have their benefits and their detractions. As far as modeling 
      the majority of T2DM cases, HFD establishes the proper etiological, pathological, 
      and treatment options. A limitation of HFD is that it requires months of feeding 
      to achieve the full spectrum of T2DM symptoms and no standard protocol has been 
      established. This paper will attempt to rectify the last limitation and argue for 
      a standard group of HFD protocols and standard analysis procedures.
FAU - Heydemann, Ahlke
AU  - Heydemann A
AUID- ORCID: 0000-0002-2626-3787
AD  - The University of Illinois at Chicago, Chicago, IL 60612, USA; The Center for 
      Cardiovascular Research, Chicago, IL 60612, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160731
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Type 2
MH  - *Diabetic Cardiomyopathies
MH  - *Diet, High-Fat
MH  - *Disease Models, Animal
MH  - Drug Evaluation, Preclinical
MH  - *Mice
MH  - Mice, Inbred Strains
MH  - Research Design
PMC - PMC4983380
EDAT- 2016/08/23 06:00
MHDA- 2017/06/10 06:00
PMCR- 2016/07/31
CRDT- 2016/08/23 06:00
PHST- 2016/05/05 00:00 [received]
PHST- 2016/06/27 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/06/10 06:00 [medline]
PHST- 2016/07/31 00:00 [pmc-release]
AID - 10.1155/2016/2902351 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:2902351. doi: 10.1155/2016/2902351. Epub 2016 Jul 31.