PMID- 27548712
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20220321
IS  - 2044-4052 (Electronic)
IS  - 2044-4052 (Linking)
VI  - 6
IP  - 8
DP  - 2016 Aug 22
TI  - Association between impaired fasting glycaemia in pediatric obesity and type 2 
      diabetes in young adulthood.
PG  - e227
LID - 10.1038/nutd.2016.34 [doi]
AB  - OBJECTIVES: In adults, impaired fasting glycemia (IFG) increases the risk for 
      type 2 diabetes mellitus (T2DM). This study aimed to investigate to which extent 
      children with obesity develop T2DM during early adulthood, and to determine 
      whether IFG and elevated hemoglobin A1c (HbA1c) in obese children are risk 
      markers for early development of T2DM. METHODS: In this prospective cohort study, 
      1620 subjects from the Swedish Childhood Obesity Treatment Registry - BORIS who 
      were ⩾18 years at follow-up and 8046 individuals in a population-based comparison 
      group, matched on gender age and living area, were included. IFG was defined 
      according to both ADA (cut-off 5.6 mmol l(-1)) and WHO (6.1 mmol l(-1)). Elevated 
      HbA1c was defined according to ADA (cut-off 39 mmol l(-1)). Main outcome was T2DM 
      medication, as a proxy for T2DM. Data on medications were retrieved from a 
      national registry. RESULTS: The childhood obesity cohort were 24 times more 
      likely to receive T2DM medications in early adulthood compared with the 
      comparison group (95% confidence interval (CI): 12.52-46). WHO-defined IFG 
      predicted future use of T2DM medication with an adjusted hazard ratio (HR) of 
      3.73 (95% CI: 1.87-7.45) compared with those who had fasting glucose levels 
      <5.6 mmol l(-1). A fasting glucose level of 5.6-6.0 mmol l(-1), that is, the 
      IFG-interval added by American Diabetes Association (ADA), did not increase the 
      use of T2DM medication more than pediatric obesity itself, adjusted HR=1.72 
      (0.84-3.52). Elevated levels of HbA1c resulted in an adjusted HR=3.12 
      (1.50-6.52). More severe degree of obesity also increased the future T2DM risk. 
      CONCLUSION: IFG according to WHO and elevated HbA1c (39-48 mmol l(-1)), but not 
      the additional fasting glucose interval added by ADA (5.6-6.0 mmol l(-1)), can be 
      considered as prediabetes in the obese pediatric population in Sweden.
FAU - Hagman, E
AU  - Hagman E
AUID- ORCID: 0000-0003-1433-2295
AD  - Division of Pediatrics, Department of Clinical Science, Intervention and 
      Technology, Karolinska Institutet, Stockholm, Sweden.
FAU - Danielsson, P
AU  - Danielsson P
AD  - Division of Pediatrics, Department of Clinical Science, Intervention and 
      Technology, Karolinska Institutet, Stockholm, Sweden.
FAU - Brandt, L
AU  - Brandt L
AD  - Unit of Clinical Epidemiology, Department of Medicine/Solna, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Ekbom, A
AU  - Ekbom A
AD  - Unit of Clinical Epidemiology, Department of Medicine/Solna, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Marcus, C
AU  - Marcus C
AD  - Division of Pediatrics, Department of Clinical Science, Intervention and 
      Technology, Karolinska Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160822
PL  - England
TA  - Nutr Diabetes
JT  - Nutrition & diabetes
JID - 101566341
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Child
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fasting/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Pediatric Obesity/*blood
MH  - Prediabetic State/blood
MH  - Prospective Studies
MH  - Registries
MH  - Sweden
MH  - Young Adult
PMC - PMC5022148
EDAT- 2016/08/23 06:00
MHDA- 2017/11/29 06:00
PMCR- 2016/08/01
CRDT- 2016/08/23 06:00
PHST- 2016/05/11 00:00 [received]
PHST- 2016/07/05 00:00 [revised]
PHST- 2016/07/08 00:00 [accepted]
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - nutd201634 [pii]
AID - 10.1038/nutd.2016.34 [doi]
PST - epublish
SO  - Nutr Diabetes. 2016 Aug 22;6(8):e227. doi: 10.1038/nutd.2016.34.