PMID- 27548889
OWN - NLM
STAT- MEDLINE
DCOM- 20170522
LR  - 20190221
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 10
DP  - 2016 Aug 1
TI  - Intereye Difference in the Microstructure of Parapapillary Atrophy in Unilateral 
      Primary Open-Angle Glaucoma.
PG  - 4187-93
LID - 10.1167/iovs.16-19059 [doi]
AB  - PURPOSE: To investigate intereye differences in the parapapillary atrophy (PPA) 
      microstructure in unilateral primary open-angle glaucoma (POAG). METHODS: 
      Bilateral optic nerves from 172 unilateral POAG patients having clinical PPA 
      shown in infrared fundus imaging were scanned using spectral-domain optical 
      coherence tomography (SD-OCT). Based on the extent of Bruch's membrane (BM) 
      within the PPA area, the PPA was divided into beta-zone (area with BM) and gamma-zone 
      (area devoid of BM). The width of each type of PPA and disc tilt angle were 
      measured in radial B-scan images. Disc tilt ratio and torsion degree were 
      determined using the radial B-scan and infrared fundus images. Measurements were 
      compared between the glaucomatous and contralateral healthy eyes, and the factors 
      associated with the presence of glaucoma were determined. RESULTS: The width of 
      beta-zone was larger in glaucomatous eyes compared with the contralateral healthy 
      eyes (283.67 +/- 157.45 vs. 214.42 +/- 145.39 mum, P < 0.001), whereas there were no 
      significant intereye differences in the gamma-zone width (P = 0.392). Eyes with POAG 
      had a larger beta-zone width (P < 0.001), and larger tilt angle (P = 0.032) compared 
      with the contralateral healthy eyes. In multivariate regression analysis, larger 
      beta-zone width (P < 0.001), and lower IOP (P = 0.001) were revealed as significant 
      factors associated with the presence of glaucoma. CONCLUSIONS: The beta-zone width 
      was revealed as a significant lateralizing factor for unilateral POAG, whereas 
      the gamma-zone was not associated with the presence of glaucoma.
FAU - Yoo, Yung Ju
AU  - Yoo YJ
FAU - Lee, Eun Ji
AU  - Lee EJ
FAU - Kim, Tae-Woo
AU  - Kim TW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Bruch Membrane/*pathology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma, Open-Angle/complications/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Optic Atrophy/*diagnosis/etiology
MH  - Optic Disk/*pathology
MH  - Prospective Studies
MH  - Tomography, Optical Coherence/*methods
EDAT- 2016/08/23 06:00
MHDA- 2017/05/23 06:00
CRDT- 2016/08/23 06:00
PHST- 2016/08/23 06:00 [entrez]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/05/23 06:00 [medline]
AID - 2545829 [pii]
AID - 10.1167/iovs.16-19059 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4187-93. doi: 10.1167/iovs.16-19059.