PMID- 27550175 OWN - NLM STAT- MEDLINE DCOM- 20171102 LR - 20220317 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 17 IP - 1 DP - 2016 Aug 22 TI - Validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology: current practice of bDMARD therapy in rheumatoid arthritis in Austria. PG - 358 LID - 10.1186/s12891-016-1207-4 [doi] LID - 358 AB - BACKGROUND: The purpose of the present study was to check the validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology, and to elucidate eventual differences with respect to disease activity (DA) in patients with rheumatoid arthritis (RA) on established biological DMARDs (bDMARDs) before inclusion into the register (EST) and beginners at the time point of inclusion (NEW) after 1 year of treatment. METHODS: RA patients with a complete follow-up of 1 year in BIOREG were divided into EST and NEW and compared with respect to DA, remission rates, concomitant synthetic DMARDs (csDMARDs) and glucocorticoid therapy (GC) at baseline and after 1-year follow-up. Safety concerns are listed. Descriptive statistics are applied. RESULTS: For 346 RA patients (284 EST, 62 NEW) out of 970 RA patients included into BIOREG, a full data set for a 1-year follow-up was available. No differences in DA were observed after 1 year as expressed by DAS28 or RADAI-5, and small differences as expressed by remission rates according to DAS28, RADAI-5 or Boolean criteria (namely approximately 1/2, 1/3 to 1/4 and 1/4 to 1/5 of the patients respectively). Sixty-four adverse events (AEs) were noted in 56 (20 %) of EST and 20 in 19 (31 %) of NEW patients. Malignancy occurred in four patients. After 1 year, 48 % of EST patients but only 16 % of NEW patients were on bDMARD monotherapy. CONCLUSION: Regarding DA, the date collected in BIOREG appeared to be valid. After 1 year of bDMARD therapy, all patients, whether EST or NEW, achieved a similar level of DA. AEs occurred more frequently during the early phase of bDMARD treatment. Austrian rheumatologists initiate bDMARD therapy in patients with lower disease levels than in other European countries, leading to high remission rates. FAU - Rintelen, Bernhard AU - Rintelen B AD - Lower Austrian State Hospital Stockerau, 2nd Department for internal medicine, Lower Austrian Center for Rheumatology, Landstrasse 18, Stockerau, 2000, Austria. bernhard.rintelen@stockerau.lknoe.at. AD - Karl Landsteiner Institute for Clinical Rheumatology, Landstrasse 18, Stockerau, 2000, Austria. bernhard.rintelen@stockerau.lknoe.at. FAU - Zwerina, Jochen AU - Zwerina J AD - Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital Vienna, Heinrich-Collinstrasse 30, Vienna, 1140, Austria. FAU - Herold, Manfred AU - Herold M AD - Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria. FAU - Singer, Franz AU - Singer F AD - BIOREG, Schlosshoferstrasse 4/4/12, Vienna, 1221, Austria. FAU - Hitzelhammer, Johann AU - Hitzelhammer J AD - Health Center Vienna Mariahilf, Wiener Gebietskrankenkasse, Mariahilfer Strasse 85-87, Vienna, 1060, Austria. FAU - Halder, Wolfgang AU - Halder W AD - Tyrolean State Hospital Hochzirl, Hochzirl, 6170, Austria. FAU - Eichbauer-Sturm, Gabriela AU - Eichbauer-Sturm G AD - Office based rheumatologist, Freistatter Strasse 16, Linz, 4040, Austria. FAU - Puchner, Rudolf AU - Puchner R AD - Office based rheumatologist, Freiung 19, Wels, 4070, Austria. FAU - Stetter, Miriam AU - Stetter M AD - Department for Internal Medicine, Lower Austrian State Hospital Amstetten, Krankenhausstrasse 21, Amstetten, 3300, Austria. FAU - Leeb, Burkhard F AU - Leeb BF AD - Lower Austrian State Hospital Stockerau, 2nd Department for internal medicine, Lower Austrian Center for Rheumatology, Landstrasse 18, Stockerau, 2000, Austria. AD - Karl Landsteiner Institute for Clinical Rheumatology, Landstrasse 18, Stockerau, 2000, Austria. AD - Medical University of Graz, Auenbruggerplatz 2, Graz, 8010, Austria. CN - BIOREG investigator group LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160822 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 RN - 0 (Antirheumatic Agents) RN - 0 (Biological Products) RN - 0 (Glucocorticoids) SB - IM EIN - BMC Musculoskelet Disord. 2016 Oct 3;17 (1):412. PMID: 27716265 MH - Aged MH - Antirheumatic Agents/adverse effects/*therapeutic use MH - Arthritis, Rheumatoid/*drug therapy MH - Austria MH - Biological Products/adverse effects/*therapeutic use MH - Drug Therapy, Combination/adverse effects MH - Female MH - Follow-Up Studies MH - Germany MH - Glucocorticoids/adverse effects/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Registries MH - Treatment Outcome PMC - PMC4994324 FIR - Bottcher, Elke IR - Bottcher E FIR - Boso, Lothar IR - Boso L FIR - Brezinschek, HansPeter IR - Brezinschek H FIR - Dunky, Attila IR - Dunky A FIR - Eberl, Gabriele IR - Eberl G FIR - Ferincz, Vera IR - Ferincz V FIR - Gaugg, Markus IR - Gaugg M FIR - Lechner, Gudrun IR - Lechner G FIR - Mai, HarsonoT H IR - Mai HH FIR - Mur, Erich IR - Mur E FIR - Mustak-Blagusz, Monika IR - Mustak-Blagusz M FIR - Nell-Duxneuner, Valerie IR - Nell-Duxneuner V FIR - Osterbauer, Andrea IR - Osterbauer A FIR - Petera, Peter IR - Petera P FIR - Sautner, Judith IR - Sautner J FIR - Steindl, Martin IR - Steindl M FIR - Stummer, Otto IR - Stummer O FIR - Teich, Gerhard IR - Teich G FIR - Thoma, Wolfgang IR - Thoma W FIR - Totzauer, Anna IR - Totzauer A FIR - Trenkler, Andrea IR - Trenkler A FIR - Vesenmayer, Armin IR - Vesenmayer A FIR - Wolf, Jeanette IR - Wolf J EDAT- 2016/08/24 06:00 MHDA- 2017/11/03 06:00 PMCR- 2016/08/22 CRDT- 2016/08/24 06:00 PHST- 2016/06/19 00:00 [received] PHST- 2016/08/05 00:00 [accepted] PHST- 2016/08/24 06:00 [entrez] PHST- 2016/08/24 06:00 [pubmed] PHST- 2017/11/03 06:00 [medline] PHST- 2016/08/22 00:00 [pmc-release] AID - 10.1186/s12891-016-1207-4 [pii] AID - 1207 [pii] AID - 10.1186/s12891-016-1207-4 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2016 Aug 22;17(1):358. doi: 10.1186/s12891-016-1207-4.