PMID- 27550182
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20181202
IS  - 1435-5604 (Electronic)
IS  - 0914-8779 (Linking)
VI  - 35
IP  - 4
DP  - 2017 Jul
TI  - Characteristics of bone turnover markers in rapidly destructive coxopathy.
PG  - 412-418
LID - 10.1007/s00774-016-0769-4 [doi]
AB  - The purpose of this study was to clarify bone turnover marker levels in rapidly 
      destructive coxopathy (RDC). Twenty patients with RDC (mean age, 72 +/- 11 years; 3 
      men, 17 postmenopausal women), 111 with osteoarthritis (OA) (age, 60 +/- 10 years; 
      15 men, 13 premenopausal women, 83 postmenopausal women), and 18 with 
      osteonecrosis of femoral head (ON) (55 +/- 14 years; 11 men, 3 premenopausal women, 
      4 postmenopausal women), and 100 patients with femoral neck fracture (FNF) 
      (81 +/- 10 years; 27 men, 73 postmenopausal women) were included. Serum 
      tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase 
      (BAP), matrix metalloproteinase-3 (MMP-3) levels, and bone mineral density (BMD) 
      of proximal femur and lumbar spine were investigated. TRACP-5b levels were 
      significantly higher in RDC than in OA and ON, whereas BAP levels were higher in 
      RDC than in OA (P < 0.05). MMP-3 levels were higher in RDC and ON than in OA 
      (P < 0.05). TRACP-5b were higher in RDC than OA (P < 0.05) and FNF (P < 0.05) in 
      performing propensity score matching; there were no differences in BMD between 
      RDC and OA. TRACP-5b showed the largest area under the curve (AUC, 0.82) 
      according to receiver operating characteristic (ROC) curve analysis for 
      diagnosing RDC against OA and ON. AUCs of BAP and MMP-3 were 0.78 and 0.74. The 
      respective sensitivities and specificities were 70.0 % and 85.3 % for TRACP-5b 
      (cutoff, 623 mU/dl), 95.0 % and 57.1 % for BAP (13.8 U/l), and 70.0 % and 76.4 % 
      for MMP-3 (52.7 ng/ml). The lack of differences in BMD suggested that high bone 
      turnover marker levels may reflect osteoclast cell activation in RDC hips. Serum 
      TRACP-5b and BAP could be RDC markers.
FAU - Abe, Hirohito
AU  - Abe H
AD  - Department of Orthopaedic Medical Engineering, Osaka University Graduate School 
      of Medicine, Suita, Japan.
FAU - Sakai, Takashi
AU  - Sakai T
AD  - Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 
      2-2 Yamadaoka, Suita, Osaka, 5650871, Japan. tsakai-osk@umin.ac.jp.
FAU - Ogawa, Takeshi
AU  - Ogawa T
AD  - Department of Orthopaedic Medical Engineering, Osaka University Graduate School 
      of Medicine, Suita, Japan.
FAU - Takao, Masaki
AU  - Takao M
AD  - Department of Orthopaedic Medical Engineering, Osaka University Graduate School 
      of Medicine, Suita, Japan.
FAU - Nishii, Takashi
AU  - Nishii T
AD  - Department of Orthopaedic Medical Engineering, Osaka University Graduate School 
      of Medicine, Suita, Japan.
FAU - Nakamura, Nobuo
AU  - Nakamura N
AD  - Center of Arthroplasty, Kyowakai Hospital, Suita, Japan.
FAU - Sugano, Nobuhiko
AU  - Sugano N
AD  - Department of Orthopaedic Medical Engineering, Osaka University Graduate School 
      of Medicine, Suita, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160822
PL  - Japan
TA  - J Bone Miner Metab
JT  - Journal of bone and mineral metabolism
JID - 9436705
RN  - 0 (Biomarkers)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alkaline Phosphatase/blood
MH  - Biomarkers/*blood
MH  - Bone Density
MH  - Bone Diseases/*blood/enzymology
MH  - *Bone Remodeling
MH  - Cohort Studies
MH  - Female
MH  - Femoral Neck Fractures/blood/enzymology
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Osteoarthritis/blood/enzymology
MH  - Propensity Score
MH  - ROC Curve
MH  - Tartrate-Resistant Acid Phosphatase/blood
OTO - NOTNLM
OT  - Bone turnover marker
OT  - Hip disease
OT  - Osteoarthritis
OT  - Rapidly destructive coxopathy
OT  - Tartrate-resistant acid phosphatase 5
EDAT- 2016/08/24 06:00
MHDA- 2018/04/17 06:00
CRDT- 2016/08/24 06:00
PHST- 2015/12/29 00:00 [received]
PHST- 2016/07/06 00:00 [accepted]
PHST- 2016/08/24 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2016/08/24 06:00 [entrez]
AID - 10.1007/s00774-016-0769-4 [pii]
AID - 10.1007/s00774-016-0769-4 [doi]
PST - ppublish
SO  - J Bone Miner Metab. 2017 Jul;35(4):412-418. doi: 10.1007/s00774-016-0769-4. Epub 
      2016 Aug 22.