PMID- 27552820
OWN - NLM
STAT- MEDLINE
DCOM- 20180802
LR  - 20180802
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 136
IP  - 1
DP  - 2017
TI  - Circulating Erythrocyte Microparticles and the Biochemical Extent of Myocardial 
      Injury in ST Elevation Myocardial Infarction.
PG  - 15-20
AB  - OBJECTIVES: Red blood cell microparticles (RBCm) have potential adverse vascular 
      effects and they have been shown to be elevated in ST elevation myocardial 
      infarction (STEMI). The purpose of this study is to investigate their 
      relationship with biochemical infarct size. METHODS: RBCm were quantified with 
      flow cytometry in blood drawn from 60 STEMI patients after a primary angioplasty. 
      The creatine kinase-myocardial brain fraction (CK-MB) was measured at predefined 
      time points and the area under the curve (AUC) was calculated. RESULTS: RBCm 
      count was correlated with CK-MB AUC (Spearman's rho = 0.83, p < 0.001). The CK-MB 
      AUC values per RBCm quartile (lower to upper) were: 3,351 (2,452-3,608), 5,005 
      (4,450-5,424), 5,903 (4,862-10,594), and 8,406 (6,848-12,782) ng x h/ml, 
      respectively. From lower to upper quartiles, the maximal troponin I values were: 
      42.2 (23.3-49.3), 49.6 (28.8-54.1), 59.2 (41.4-77.3), and 69.1 (48.0-77.5) ng/ml 
      (p = 0.005). In multivariable analysis, RBCm remained a significant predictor of 
      CK-MB AUC (standardized beta = 0.63, adjusted p = 0.001). CONCLUSIONS: Erythrocyte 
      microparticles appear to be related to the total myocardial damage biomarker 
      output. The exact pathophysiologic routes, if any, for this interaction remain to 
      be identified. However, these results suggest that erythrocytes may be a - thus 
      far virtually ignored - player in the pathogenesis of ischemic injury.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Giannopoulos, Georgios
AU  - Giannopoulos G
AD  - 2nd Department of Cardiology, Attikon University Hospital, National and 
      Kapodistrean University of Athens Medical School, Athens, Greece.
FAU - Vrachatis, Dimitrios A
AU  - Vrachatis DA
FAU - Oudatzis, Georgios
AU  - Oudatzis G
FAU - Paterakis, Georgios
AU  - Paterakis G
FAU - Angelidis, Christos
AU  - Angelidis C
FAU - Koutivas, Athanasios
AU  - Koutivas A
FAU - Sianos, Georgios
AU  - Sianos G
FAU - Cleman, Michael W
AU  - Cleman MW
FAU - Filippatos, Gerasimos
AU  - Filippatos G
FAU - Lekakis, John
AU  - Lekakis J
FAU - Deftereos, Spyridon
AU  - Deftereos S
LA  - eng
PT  - Journal Article
DEP - 20160824
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - *Cell-Derived Microparticles
MH  - Creatine Kinase, MB Form/*blood
MH  - Erythrocyte Count
MH  - *Erythrocytes
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardium/*pathology
MH  - Necrosis
MH  - ST Elevation Myocardial Infarction/*blood/pathology
MH  - Troponin I/*blood
EDAT- 2016/08/25 06:00
MHDA- 2018/08/03 06:00
CRDT- 2016/08/25 06:00
PHST- 2015/12/28 00:00 [received]
PHST- 2016/05/09 00:00 [accepted]
PHST- 2016/08/25 06:00 [pubmed]
PHST- 2018/08/03 06:00 [medline]
PHST- 2016/08/25 06:00 [entrez]
AID - 000447625 [pii]
AID - 10.1159/000447625 [doi]
PST - ppublish
SO  - Cardiology. 2017;136(1):15-20. doi: 10.1159/000447625. Epub 2016 Aug 24.