PMID- 27552900
OWN - NLM
STAT- MEDLINE
DCOM- 20161214
LR  - 20181202
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 16
IP  - 1
DP  - 2016 Aug 23
TI  - Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) 
      antibodies in Sardinian multiple sclerosis patients: associated or independent 
      risk factors?
PG  - 148
LID - 10.1186/s12883-016-0669-1 [doi]
LID - 148
AB  - BACKGROUND: Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 
      haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for 
      multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, 
      *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are 
      predisposing factors. We studied the correlation between MAP and HLA. METHODS: 
      Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, 
      DRB1-DQB1 genotyping was performed. The haplotypes were classified as 
      predisposing, neutral or protective. RESULTS: Anti-MAP2694 were found in 23 % of 
      subjects carrying one protective HLA versus 32 % without (p = 0.04). CONCLUSIONS: 
      We showed a lower frequency of Abs in patients with protective HLA. These 
      haplotypes could have a protective role for both MS and MAP.
FAU - Frau, J
AU  - Frau J
AD  - Multiple Sclerosis Centre, Department of Public Health, Clinical and Molecular 
      Medicine, University of Cagliari, Cagliari, Italy. jessicafrau@hotmail.it.
FAU - Cossu, D
AU  - Cossu D
AD  - Department of Biomedical Sciences, Section of Experimental and Clinical 
      Microbiology, University of Sassari, Sassari, Italy.
FAU - Sardu, C
AU  - Sardu C
AD  - Department of Public Health, Clinical and Molecular Medicine, University of 
      Cagliari, Cagliari, Italy.
FAU - Mameli, G
AU  - Mameli G
AD  - Department of Biomedical Sciences, Section of Experimental and Clinical 
      Microbiology, University of Sassari, Sassari, Italy.
FAU - Coghe, G
AU  - Coghe G
AD  - Multiple Sclerosis Centre, Department of Public Health, Clinical and Molecular 
      Medicine, University of Cagliari, Cagliari, Italy.
FAU - Lorefice, L
AU  - Lorefice L
AD  - Multiple Sclerosis Centre, Department of Public Health, Clinical and Molecular 
      Medicine, University of Cagliari, Cagliari, Italy.
FAU - Fenu, G
AU  - Fenu G
AD  - Multiple Sclerosis Centre, Department of Public Health, Clinical and Molecular 
      Medicine, University of Cagliari, Cagliari, Italy.
FAU - Tranquilli, S
AU  - Tranquilli S
AD  - Multiple Sclerosis Centre, Department of Public Health, Clinical and Molecular 
      Medicine, University of Cagliari, Cagliari, Italy.
FAU - Sechi, L A
AU  - Sechi LA
AD  - Department of Biomedical Sciences, Section of Experimental and Clinical 
      Microbiology, University of Sassari, Sassari, Italy.
FAU - Marrosu, M G
AU  - Marrosu MG
AD  - Multiple Sclerosis Centre, Department of medical sciences, University of 
      Cagliari, Cagliari, Italy.
FAU - Cocco, E
AU  - Cocco E
AD  - Multiple Sclerosis Centre, Department of Public Health, Clinical and Molecular 
      Medicine, University of Cagliari, Cagliari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160823
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (Antibodies)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Antibodies/immunology
MH  - Female
MH  - Genotype
MH  - HLA-DQ beta-Chains/*immunology
MH  - HLA-DRB1 Chains/*immunology
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/*immunology
MH  - Mycobacterium avium/*immunology
MH  - Risk Factors
PMC - PMC4994163
OTO - NOTNLM
OT  - HLA
OT  - Multiple sclerosis
OT  - Mycobacterium avium subspecies paratuberculosis
OT  - Sardinia
EDAT- 2016/08/25 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/08/23
CRDT- 2016/08/25 06:00
PHST- 2016/01/14 00:00 [received]
PHST- 2016/08/10 00:00 [accepted]
PHST- 2016/08/25 06:00 [entrez]
PHST- 2016/08/25 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/08/23 00:00 [pmc-release]
AID - 10.1186/s12883-016-0669-1 [pii]
AID - 669 [pii]
AID - 10.1186/s12883-016-0669-1 [doi]
PST - epublish
SO  - BMC Neurol. 2016 Aug 23;16(1):148. doi: 10.1186/s12883-016-0669-1.