PMID- 27553604
OWN - NLM
STAT- MEDLINE
DCOM- 20170519
LR  - 20170817
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 179
IP  - 20
DP  - 2016 Nov 19
TI  - Absence of significant adverse events following thalidomide administration in 
      bitches diagnosed with mammary gland carcinomas.
PG  - 514
LID - 10.1136/vr.103764 [doi]
AB  - The aim of the study was to evaluate the incidence of adverse events (AEs) in 
      female dogs diagnosed with advanced clinical stage mammary gland neoplasms 
      following treatment with thalidomide. A prospective analysis of 29 female dogs 
      treated with a high dose (HD) of 20 mg/kg/day of thalidomide for three months 
      followed by a low dose (LD) of 10 mg/kg/day of thalidomide for three months was 
      performed. All patients underwent physical examination, complete blood count, 
      serum biochemistry profile, thoracic radiographs, and abdominal ultrasound 
      analysis before the treatment and after the HD and LD. Clinical AEs were absent 
      in 16/29 (55.17 per cent) patients following HD. An initial 3-5 day period of 
      somnolence was described in 4/29 (13.79 per cent), prolonged somnolence in 5/29 
      (17.24 per cent), a short period of somnolence lasting only a few hours in 3/29 
      (10.34 per cent), and difficulty to rouse was described in 5/29 (17.24 per cent) 
      cases. Two patients (6.89 per cent) presented with prolonged somnolence that 
      interfered with activities of daily living, resulting in anticipation of the dose 
      reduction to the proposed LD after 15 days of the HD treatment. Following dose 
      reduction, AE improvement was observed in all patients. Albeit remaining within 
      the reference ranges, erythrocytes, haematocrit, total leucocyte count, 
      neutrophils, lymphocytes, monocytes and gamma-glutamyltranspeptidase showed 
      significant alteration associated to thalidomide treatment.
CI  - British Veterinary Association.
FAU - de Campos, C B
AU  - de Campos CB
AD  - Department of Veterinary Clinic and Surgery, School of Agricultural and 
      Veterinary Sciences of the Sao Paulo State University (FCAV/UNESP) - Jaboticabal 
      Campus, Jaboticabal, Brazil.
FAU - Lavalle, G E
AU  - Lavalle GE
AD  - Department of Veterinary Clinic and Surgery, Veterinary School, Federal 
      University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
FAU - Fialho Ligorio, S
AU  - Fialho Ligorio S
AD  - Department of Pharmaceutical and Biotechnological Development, Fundacao Ezequiel 
      Dias, Belo Horizonte, Brazil.
FAU - Camargo Nunes, F
AU  - Camargo Nunes F
AD  - Laboratory of Comparative Pathology, Department of General Pathology, Federal 
      University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
FAU - Carneiro, R A
AU  - Carneiro RA
AD  - Department of Veterinary Clinic and Surgery, Veterinary School, Federal 
      University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
FAU - Amorim, R L
AU  - Amorim RL
AD  - Department of Veterinary Clinics, College of Veterinary Medicine and Animal 
      Science, Sao Paulo State University (FMVZ/UNESP) - Botucatu Campus, Botucatu, 
      Brazil.
FAU - Cassali, G D
AU  - Cassali GD
AD  - Laboratory of Comparative Pathology, Department of General Pathology, Federal 
      University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160823
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 4Z8R6ORS6L (Thalidomide)
SB  - IM
MH  - Animals
MH  - Carcinoma/drug therapy/pathology/*veterinary
MH  - Dog Diseases/*drug therapy/pathology
MH  - Dogs
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Mammary Neoplasms, Animal/*drug therapy/pathology
MH  - Neoplasm Staging
MH  - Prospective Studies
MH  - Thalidomide/*administration & dosage/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adverse events
OT  - Dogs
OT  - Mammary gland
OT  - Oncology
OT  - Thalidomide
EDAT- 2016/08/25 06:00
MHDA- 2017/05/20 06:00
CRDT- 2016/08/25 06:00
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/08/25 06:00 [pubmed]
PHST- 2017/05/20 06:00 [medline]
PHST- 2016/08/25 06:00 [entrez]
AID - vr.103764 [pii]
AID - 10.1136/vr.103764 [doi]
PST - ppublish
SO  - Vet Rec. 2016 Nov 19;179(20):514. doi: 10.1136/vr.103764. Epub 2016 Aug 23.