PMID- 27553940
OWN - NLM
STAT- MEDLINE
DCOM- 20170522
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 27
IP  - 5
DP  - 2017 May
TI  - Resting-state fMRI revealed different brain activities responding to valproic 
      acid and levetiracetam in benign epilepsy with central-temporal spikes.
PG  - 2137-2145
LID - 10.1007/s00330-016-4531-z [doi]
AB  - OBJECTIVES: Our aim was to investigate regional difference in brain activities in 
      response to antiepileptic drug (AED) medications in benign epilepsy with 
      central-temporal spikes (BECTS) using resting-state functional magnetic resonance 
      imaging (fMRI). METHODS: Fifty-seven patients with BECTS underwent resting-state 
      fMRI scans after receiving either valproic acid (VPA) (n = 15), levetiracetam 
      (LEV) (n = 21), or no medication (n = 21). fMRI regional homogeneity (ReHo) 
      parameter among the three groups of patients were compared and were correlated 
      with total doses of AED in the two medicated groups. RESULTS: Compared with 
      patients on no-medication, patients receiving either VPA or LEV showed decreased 
      ReHo in the central-temporal region, frontal cortex, and thalamus. In particular, 
      the VPA group showed greater ReHo decrease in the thalamus and milder in cortices 
      and caudate heads compared with the LEV group. In addition, the VPA group 
      demonstrated a negative correlation between ReHo values in the central-temporal 
      region and medication dose. CONCLUSION: Both VPA and LEV inhibit resting-state 
      neural activity in the central-temporal region, which is the main epileptogenic 
      focus of BECTS. VPA reduced brain activity in the cortical epileptogenic regions 
      and thalamus evenly, whereas LEV reduced brain activity predominantly in the 
      cortices. Interestingly, VPA showed a cumulative effect on inhibiting brain 
      activity in the epileptogenic regions in BECTS. KEY POINTS: * Regional 
      differences in brain activity in response to different AEDs in BECTS. * AEDs 
      inhibit resting-state neural activity in epileptogenic and subcortical regions in 
      BECTS. * Valproic acid effect on the cortical epileptogenic regions and thalamus 
      evenly. * Levetiracetam effect seen predominantly in cortices. * Valproic acid 
      has a cumulative effect on inhibiting brain activity in epileptogenic regions.
FAU - Zhang, Qirui
AU  - Zhang Q
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, 305#, Eastern Zhongshan Rd, Nanjing, 210002, China.
FAU - Yang, Fang
AU  - Yang F
AD  - Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 
      Nanjing, 210002, China.
FAU - Hu, Zheng
AU  - Hu Z
AD  - Department of Neurology, Nanjing Children's Hospital, Nanjing, 210029, China.
FAU - Zhang, Zhiqiang
AU  - Zhang Z
AUID- ORCID: 0000-0002-3993-7330
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, 305#, Eastern Zhongshan Rd, Nanjing, 210002, China. 
      zhangzq2001@126.com.
FAU - Xu, Qiang
AU  - Xu Q
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, 305#, Eastern Zhongshan Rd, Nanjing, 210002, China.
FAU - Dante, Mantini
AU  - Dante M
AD  - Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Belgium.
FAU - Wu, Han
AU  - Wu H
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, 305#, Eastern Zhongshan Rd, Nanjing, 210002, China.
FAU - Li, Zhipeng
AU  - Li Z
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, 305#, Eastern Zhongshan Rd, Nanjing, 210002, China.
FAU - Li, Qian
AU  - Li Q
AD  - Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 
      Nanjing, 210002, China.
FAU - Li, Kai
AU  - Li K
AD  - Laboratory of Molecular Medicine, Suzhou University, Suzhou, 215000, China.
FAU - Lu, Guangming
AU  - Lu G
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, 305#, Eastern Zhongshan Rd, Nanjing, 210002, China. 
      cjr.luguangming@vip.163.com.
LA  - eng
PT  - Journal Article
DEP - 20160823
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Anticonvulsants)
RN  - 44YRR34555 (Levetiracetam)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - ZH516LNZ10 (Piracetam)
SB  - IM
MH  - Anticonvulsants/administration & dosage/*pharmacology/therapeutic use
MH  - Brain/diagnostic imaging/*drug effects/physiopathology
MH  - Child
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography
MH  - Epilepsy/drug therapy/*physiopathology
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/drug effects/physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Levetiracetam
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Piracetam/administration & dosage/*analogs & derivatives/pharmacology/therapeutic 
      use
MH  - Temporal Lobe/diagnostic imaging/drug effects/physiopathology
MH  - Thalamus/diagnostic imaging/drug effects/physiopathology
MH  - Valproic Acid/administration & dosage/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - BECTS
OT  - Levetiracetam
OT  - ReHo
OT  - Resting-state fMRI
OT  - Valproic acid
EDAT- 2016/08/25 06:00
MHDA- 2017/05/23 06:00
CRDT- 2016/08/25 06:00
PHST- 2016/05/13 00:00 [received]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2016/07/12 00:00 [revised]
PHST- 2016/08/25 06:00 [pubmed]
PHST- 2017/05/23 06:00 [medline]
PHST- 2016/08/25 06:00 [entrez]
AID - 10.1007/s00330-016-4531-z [pii]
AID - 10.1007/s00330-016-4531-z [doi]
PST - ppublish
SO  - Eur Radiol. 2017 May;27(5):2137-2145. doi: 10.1007/s00330-016-4531-z. Epub 2016 
      Aug 23.