PMID- 27554132
OWN - NLM
STAT- MEDLINE
DCOM- 20190423
LR  - 20211204
IS  - 1871-403X (Print)
IS  - 1871-403X (Linking)
VI  - 12
IP  - Suppl 2
DP  - 2018 Jan-Feb
TI  - Relationship between serum betatrophin levels and the first-phase of 
      glucose-stimulated insulin secretion.
PG  - 9-15
LID - S1871-403X(16)30075-8 [pii]
LID - 10.1016/j.orcp.2016.08.004 [doi]
AB  - AIMS: To examine circulating betatrophin concentrations in subjects with 
      different glucose tolerance status and to investigate the relationship between 
      serum betatrophin levels and first-phase of glucose-stimulated insulin secretion. 
      METHODS: Serum betatrophin concentrations were measured in 110 age- and 
      sex-matched subjects: 47 newly diagnosed type 2 diabetes mellitus (T2DM), 29 
      impaired glucose tolerance (IGT) and 34 normal glucose tolerance (NGT). Oral 
      glucose tolerance test and intravenous glucose tolerance test were performed to 
      assess glucose tolerance and first-phase of glucose-stimulated insulin secretion. 
      RESULTS: Serum betatrophin levels were significantly higher in the T2DM and IGT 
      group than in the NGT group (2.10+/-1.16ng/mL vs 0.77+/-0.44ng/mL, 1.73+/-1.28ng/mL vs 
      0.77+/-0.44ng/mL; P<0.01). The AIR and AUC among the three groups showed a 
      progressive decrease from the NGT to IGT group with the lowest value in the T2DM 
      group (P<0.01). Betatrophin were found to be positively correlated with BMI, 
      waist circumference (WC), homeostatic model assessment of insulin resistance 
      (HOMA-IR) and triglyceride (TG), and inversely associated with HDL-c (all 
      P<0.01), but not significantly correlated with 0-10min insulin the area under the 
      curve (AUC) and acute insulin response (AIR) (P>0.05). Stepwise multiple 
      regression analysis showed that HOMA-IR and TG were independently related to 
      betatrophin (P<0.05). CONCLUSION: Serum betatrophin concentrations were higher in 
      T2DM and IGT, and were closely related to glucolipid disorder, insulin 
      resistance, but not related to the first-phase of glucose-stimulated insulin 
      secretion.
CI  - Copyright (c) 2016 Asia Oceania Association for the Study of Obesity. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Qu, Hua
AU  - Qu H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Wang, Hang
AU  - Wang H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Duan, Yang
AU  - Duan Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Liu, Fang
AU  - Liu F
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Feng, Zhengping
AU  - Feng Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Deng, Huacong
AU  - Deng H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China. Electronic address: deng_huacong@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160821
PL  - Netherlands
TA  - Obes Res Clin Pract
JT  - Obesity research & clinical practice
JID - 101303911
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Blood Glucose)
RN  - 0 (Peptide Hormones)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins/*blood
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/*metabolism/physiopathology
MH  - Female
MH  - Glucose Intolerance/blood/*metabolism/physiopathology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Insulin Secretion/*physiology
MH  - Male
MH  - Middle Aged
MH  - Peptide Hormones/*blood
MH  - Postprandial Period/physiology
OTO - NOTNLM
OT  - Betatrophin
OT  - Diabetes
OT  - First-phase of insulin secretion
OT  - Intravenous glucose tolerance test
EDAT- 2016/08/25 06:00
MHDA- 2019/04/24 06:00
CRDT- 2016/08/25 06:00
PHST- 2016/03/23 00:00 [received]
PHST- 2016/07/20 00:00 [revised]
PHST- 2016/08/09 00:00 [accepted]
PHST- 2016/08/25 06:00 [pubmed]
PHST- 2019/04/24 06:00 [medline]
PHST- 2016/08/25 06:00 [entrez]
AID - S1871-403X(16)30075-8 [pii]
AID - 10.1016/j.orcp.2016.08.004 [doi]
PST - ppublish
SO  - Obes Res Clin Pract. 2018 Jan-Feb;12(Suppl 2):9-15. doi: 
      10.1016/j.orcp.2016.08.004. Epub 2016 Aug 21.