PMID- 27554438
OWN - NLM
STAT- MEDLINE
DCOM- 20180328
LR  - 20181202
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 30
IP  - 8
DP  - 2016 Nov-Dec
TI  - Plasma copeptin and functional outcome in patients with ischemic stroke and type 
      2 diabetes.
PG  - 1532-1536
LID - S1056-8727(16)30332-4 [pii]
LID - 10.1016/j.jdiacomp.2016.07.030 [doi]
AB  - BACKGROUND: The activation of the arginine vasopressin system may be involved in 
      the pathology of stroke and diabetes. In this study, we therefore evaluated the 
      short-term prognostic value of early measurement of plasma copeptin levels in 
      Chinese patients with type 2 diabetes mellitus (T2DM) and acute ischemic stroke 
      (AIS). METHODS: From July 2014 to June 2015, all T2DM patients with first-ever 
      AIS were included. Plasma levels of copeptin were tested at admission. The 
      prognostic value of copeptin to predict the functional outcome and mortality 
      3months after stroke was compared with the National Institutes of Health Stroke 
      Scale score and with other known outcome predictors. RESULTS: We recorded 247 
      stroke patients with T2DM. The copeptin levels were obtained in those patients 
      with a median value of 14.3pmol/L (IQR, 9.5-17.1pmol/L). At 3-month follow-up, a 
      favorable functional outcome was found in 86 patients (34.8%). Plasma copeptin 
      levels in patients with an unfavorable outcome were significantly greater than 
      those in patients with a favorable outcome (16.2 [IQR, 12.2-20.3] vs. 12.4 [IQR, 
      8.6-15.2] pmol/L; Z=5.399; P<0.0001). In univariate logistic regression analysis, 
      with an unadjusted OR of 1.123 (95% CI, 1.072-1.177, P<0.001), copeptin had a 
      strong association with unfavorable functional outcome. In multivariate analyses, 
      a copeptin level in the highest inter-quartile (>17.1pmol/L) was associated with 
      a higher risk of unfavorable functional outcome (OR=4.62; 95% CI=2.63-9.21; 
      P<0.001). After adjusting for other outcome predictors, a copeptin level in the 
      highest inter-quartile (>17.1pmol/L) was associated with a higher risk of 
      mortality (OR=5.12; 95% CI=2.20-11.38; P<0.001). CONCLUSION: Our study suggested 
      that copeptin levels may reliably predict short-term stroke prognosis at its 
      onset in Chinese patients with T2DM and stroke.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Wang, Chi-Bo
AU  - Wang CB
AD  - Department of Neurosurgery, Yantaishan Hospital, Yantai, China.
FAU - Zong, Miao
AU  - Zong M
AD  - Department of Neurosurgery, Beijing Electric Power Hospital of the Capital 
      Medical University, Beijing, China.
FAU - Lu, Shi-Qing
AU  - Lu SQ
AD  - Department of Neurosurgery, Yantaishan Hospital, Yantai, China.
FAU - Tian, Zhuo
AU  - Tian Z
AD  - Department of Neurosurgery, Yantai Hospital of Tradition Chinese Medicine, 
      Yantai, China. Electronic address: Lihunhb69@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160730
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Glycopeptides)
RN  - 0 (copeptins)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain Ischemia/blood/diagnosis
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis
MH  - Female
MH  - Glycopeptides/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Stroke/*blood/diagnosis
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - Chinese
OT  - Copeptin
OT  - Prognostic biomarker
OT  - Type 2 diabetes
EDAT- 2016/08/25 06:00
MHDA- 2018/03/29 06:00
CRDT- 2016/08/25 06:00
PHST- 2016/05/14 00:00 [received]
PHST- 2016/06/13 00:00 [revised]
PHST- 2016/07/26 00:00 [accepted]
PHST- 2016/08/25 06:00 [pubmed]
PHST- 2018/03/29 06:00 [medline]
PHST- 2016/08/25 06:00 [entrez]
AID - S1056-8727(16)30332-4 [pii]
AID - 10.1016/j.jdiacomp.2016.07.030 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2016 Nov-Dec;30(8):1532-1536. doi: 
      10.1016/j.jdiacomp.2016.07.030. Epub 2016 Jul 30.