PMID- 2755559
OWN - NLM
STAT- MEDLINE
DCOM- 19890831
LR  - 20190908
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 10
IP  - 1
DP  - 1989 Jan-Feb
TI  - Leg flexion conditioning in the rat: its advantages and disadvantages as a model 
      system of age-related changes in associative learning.
PG  - 59-65
AB  - Twelve- and 28-month-old Fischer 344 rats of both sexes received five 60-trial 
      sessions of Pavlovian conditioning in which the CS was a 75 dB, 10,000 Hz tone, 
      and the US was a 0.5-mA, 0.5-sec duration footshock. Right foreleg flexion was 
      measured as the conditioned response (CR). Other animals received a random 
      sequence of unpaired tones and footshock and served as pseudoconditioning control 
      groups. Interstimulus intervals (ISIs) of 1.5 and 3.5 sec were studied. The 
      longer ISI resulted in higher rates of responding in both the conditioning and 
      pseudoconditioning groups. However, with the exception of the young males, all 
      animals showed significantly higher levels of responding in the conditioning 
      groups. Females also showed faster acquisition and higher levels of responding 
      than males. A significant sex by age by sessions interaction occurred, suggesting 
      that old males may be somewhat retarded in acquiring the leg flexion CR compared 
      to the other groups of animals. Old males were also slower to reach a criterion 
      of 5 successive CRs than either young males or young or old females.
FAU - Prescott, L
AU  - Prescott L
AD  - Neuroscience Laboratory, VA Medical Center, Columbia, SC 29201.
FAU - Buchanan, S L
AU  - Buchanan SL
FAU - Powell, D A
AU  - Powell DA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Aging/physiology/*psychology
MH  - Animals
MH  - Association Learning/*physiology
MH  - Conditioning, Classical/*physiology
MH  - Female
MH  - Forelimb/*physiology
MH  - Learning/*physiology
MH  - Male
MH  - Models, Psychological
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - S0197-4580(89)80012-0 [pii]
AID - 10.1016/s0197-4580(89)80012-0 [doi]
PST - ppublish
SO  - Neurobiol Aging. 1989 Jan-Feb;10(1):59-65. doi: 10.1016/s0197-4580(89)80012-0.