PMID- 27556823
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20190624
IS  - 1533-4058 (Electronic)
IS  - 1533-4058 (Linking)
VI  - 26
IP  - 5
DP  - 2018 May/Jun
TI  - Proximal CD13 Versus Distal GATA-3 Expression in Renal Neoplasia According to WHO 
      2016 Classification.
PG  - 316-323
LID - 10.1097/PAI.0000000000000435 [doi]
AB  - Little is known about the aminopeptidase CD13 in renal neoplasia according to the 
      new 2016 World Health Organization renal tumor classification. We selected 175 
      cases, including 79 clear cell, 31 papillary, 24 chromophobe, 8 clear cell 
      papillary renal cell carcinomas (RCCs), 21 oncoytomas, and 12 microphthalmia 
      transcription factor family translocation RCCs: 4 t(6;11)/transcription factor EB 
      (TFEB), 7 t(Xp11) with 2 cystic variants and 1 t(X;17). GATA binding protein 3 
      (GATA-3) was inserted as control. Expression of proximal antigen CD13 was 
      observed in 63/79 (80%) clear cell, 25/31 (81%) papillary, 3/8 (37%) clear cell 
      papillary, 1/4 (25%) t(6;11)/TFEB, 2/7 (28%) cystic t(Xp11), and in 1/1 t(X;17) 
      RCCs. All chromophobe RCC (0/24) and all oncocytomas (0/21) resulted negative. 
      CD10 was seen in 76/79 (96%) clear cell, 15/31 (48%) papillary, 10/24 (42%) 
      chromophobe, 1/8 (12%) clear cell papillary RCCs, 4/21 (19%) oncocytomas, 1/4 
      (25%) t(6;11)/TFEB, 2/7 (29%) cystic t(Xp11), and in 1/1 t(X;17) RCCs. GATA-3 was 
      positive in 3/7 (42%) clear cell papillary RCCs and negative in all remaining 
      RCCs, except a single chromophobe RCC and a single oncocytoma. We concluded that: 
      (1) CD13 and GATA-3 immunostains may serve as a diagnostic aid in differentiating 
      subtypes of RCC; (2) CD13 is always absent in chromophobe RCC and oncocytomas, 
      whereas CD10 can be immunoexpressed in both; (3) CD13 should be included in a 
      panel of antibodies to distinguish "proximal renal tumors" from "distal renal 
      tumors" and between clear cell RCC versus microphthalmia transcription factor 
      family translocations RCCs; and (4) when present, GATA-3 is specific for clear 
      cell papillary RCC.
FAU - Brunelli, Matteo
AU  - Brunelli M
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Erdini, Francesco
AU  - Erdini F
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Cima, Luca
AU  - Cima L
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Eccher, Albino
AU  - Eccher A
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Fioravanzo, Adele
AU  - Fioravanzo A
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Gobbo, Stefano
AU  - Gobbo S
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Segala, Diego
AU  - Segala D
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Ghimenton, Claudio
AU  - Ghimenton C
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Mazzoleni, Guido
AU  - Mazzoleni G
AD  - Pathology Unit, San Maurizio Hospital, Bolzano.
FAU - Munari, Enrico
AU  - Munari E
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
FAU - Carella, Rodolfo
AU  - Carella R
AD  - Pathology Unit, San Maurizio Hospital, Bolzano.
FAU - Martignoni, Guido
AU  - Martignoni G
AD  - Department of Diagnostics and Public Health, University of Verona, Verona.
AD  - Pathology Unit, Pederzoli Hospital, Peschiera Del Garda, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Appl Immunohistochem Mol Morphol
JT  - Applied immunohistochemistry & molecular morphology : AIMM
JID - 100888796
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (TFEB protein, human)
RN  - EC 3.4.11.2 (CD13 Antigens)
SB  - IM
MH  - Adenoma, Oxyphilic/*diagnosis
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics
MH  - Biomarkers, Tumor/*metabolism
MH  - CD13 Antigens/*metabolism
MH  - Carcinoma, Papillary/*diagnosis
MH  - Carcinoma, Renal Cell/*diagnosis
MH  - Diagnosis, Differential
MH  - GATA3 Transcription Factor/*metabolism
MH  - Humans
MH  - Immunochemistry
MH  - Kidney Neoplasms/*diagnosis
MH  - Male
MH  - Translocation, Genetic
MH  - World Health Organization
EDAT- 2016/08/25 06:00
MHDA- 2019/06/25 06:00
CRDT- 2016/08/25 06:00
PHST- 2016/08/25 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2016/08/25 06:00 [entrez]
AID - 10.1097/PAI.0000000000000435 [doi]
PST - ppublish
SO  - Appl Immunohistochem Mol Morphol. 2018 May/Jun;26(5):316-323. doi: 
      10.1097/PAI.0000000000000435.