PMID- 27558012
OWN - NLM
STAT- MEDLINE
DCOM- 20170126
LR  - 20181113
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 16
IP  - 1
DP  - 2016 Aug 24
TI  - A system biology approach to understanding the molecular mechanisms of 
      Gubentongluo decoction acting on IgA Nephropathy.
PG  - 312
LID - 10.1186/s12906-016-1268-9 [doi]
LID - 312
AB  - BACKGROUND: Traditional Chinese medicine (TCM) has been widely used in treating 
      various diseases in eastern Asia for several thousand years, and is becoming 
      increasingly popular in western countries. Gubentongluo (GBTL) decoction, as a 
      classic TCM formula, is commonly applied to treat IgA Nephropathy (IgAN) in 
      China. To date, however, the pharmacological/molecular mechanisms of GBTL have 
      not been fully elucidated. METHOD: In the present study, we used a system 
      biological approach to explore these mechanisms acting on IgAN. RESULTS: First, 
      we found 3876 potential target proteins for GBTL (based on TCMID) and 25 known 
      IgAN associated biomarkers (based on the OMIM or IPA database).16 of the latter 
      biomarkers were direct targets of 6 of the 9 herbs in GBTL, suggesting that these 
      components play a vital role in treating IgAN. Second, we showed that these 6 
      herbs mainly regulate the immune system and renin-angiotensin system, imbalance 
      in which is the main factor leading to IgAN. Importantly, HUANG QI links with 14 
      biomarkers, indicating that it is the most important herb in GBTL for treating 
      IgAN. Also, relationships of other herbs with IgAN were explored. Third, we 
      demonstrated that the remaining 9 IgAN associated proteins are responses to 
      biological processes, such as antigen processing, protein ubiquitination and cell 
      cycle regulation, which are crucial for IgAN development. Finally, we found that 
      GBTL could induce a significant increase in the levels of two target gene: TNF 
      and NOS2. CONCLUSIONS: Further studies are called to develop/modify the formula 
      of GBTL, in order to enhance its effect on IgAN.
FAU - Shen, Peicheng
AU  - Shen P
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, 528 Zhangheng Road, Pudong, Shanghai, 201203, 
      People's Republic of China.
AD  - Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (14DZ2273220), 
      Shanghai, People's Republic of China.
FAU - Shen, Jiaojiao
AU  - Shen J
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, 528 Zhangheng Road, Pudong, Shanghai, 201203, 
      People's Republic of China.
AD  - Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (14DZ2273220), 
      Shanghai, People's Republic of China.
FAU - Sun, Chuan
AU  - Sun C
AD  - Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic 
      of China.
FAU - Yang, Xuejun
AU  - Yang X
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, 528 Zhangheng Road, Pudong, Shanghai, 201203, 
      People's Republic of China.
AD  - Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (14DZ2273220), 
      Shanghai, People's Republic of China.
FAU - He, Liqun
AU  - He L
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, 528 Zhangheng Road, Pudong, Shanghai, 201203, 
      People's Republic of China. Liqun-he12@sohu.com.
AD  - Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (14DZ2273220), 
      Shanghai, People's Republic of China. Liqun-he12@sohu.com.
LA  - eng
PT  - Journal Article
DEP - 20160824
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Biomarkers)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Proteins)
RN  - 0 (Proteome)
SB  - IM
MH  - Animals
MH  - Biomarkers/*analysis/metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Glomerulonephritis, IGA/*metabolism
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Proteins/analysis/metabolism
MH  - Proteome
MH  - Signal Transduction/*drug effects/immunology
MH  - Systems Biology
PMC - PMC4997663
OTO - NOTNLM
OT  - Gubentongluo decoction
OT  - IgA Nephropathy
OT  - Network
OT  - Proteins
OT  - Traditional Chinese Medicine
EDAT- 2016/08/26 06:00
MHDA- 2017/01/27 06:00
PMCR- 2016/08/24
CRDT- 2016/08/26 06:00
PHST- 2015/01/30 00:00 [received]
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/08/26 06:00 [entrez]
PHST- 2016/08/26 06:00 [pubmed]
PHST- 2017/01/27 06:00 [medline]
PHST- 2016/08/24 00:00 [pmc-release]
AID - 10.1186/s12906-016-1268-9 [pii]
AID - 1268 [pii]
AID - 10.1186/s12906-016-1268-9 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2016 Aug 24;16(1):312. doi: 10.1186/s12906-016-1268-9.