PMID- 27558013
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20211204
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Print)
IS  - 2059-2302 (Linking)
VI  - 88
IP  - 3
DP  - 2016 Sep
TI  - HLA class I variation in Iranian Lur and Kurd populations: high haplotype and 
      allotype diversity with an abundance of KIR ligands.
PG  - 87-99
LID - 10.1111/tan.12852 [doi]
AB  - HLA-A, -B and -C alleles of 285 individuals, representing three Iranian Lur 
      populations and one Iranian Kurd population were sequenced completely, yielding 
      human leukocyte antigen (HLA) class I genotypes at high resolution and filling 
      four fields of the official HLA nomenclature. Each population has 87-99 alleles, 
      evenly distributed between the three HLA class I genes, 145 alleles being 
      identified in total. These alleles were already known, named and deposited in the 
      HLA database. The alleles form 316 different HLA A-B-C haplotypes, with each 
      population having between 80 and 112 haplotypes. The four Iranian populations 
      form a related group that is distinguished from other populations, including 
      other Iranians. All four KIR ligands - the A3/11, Bw4, C1 and C2 epitopes - are 
      well represented, particularly Bw4, which is carried by three high-frequency 
      allotypes: HLA-A*24:02, HLA-A*32:01 and HLA-B*51:01. In the Lur and Kurd 
      populations, between 82% and 94% of individuals have the Bw4 epitope, the ligand 
      for KIR3DL1. HLA-B*51:01 is likely of Neandertal origin and associated with 
      Behcet's disease, also known as the Silk Road disease. The Lordegan Lur have the 
      highest frequency of HLA-B*51:01 in the world. This allele is present on 46 Lur 
      and Kurd haplotypes. Present at lower frequency is HLA-B*51:08, which is also 
      associated with Behcet's disease. In the four Iranian populations, 31 haplotypes 
      encode both Bw4(+) HLA-A and Bw4(+) HLA-B, a dual combination of Bw4 epitopes 
      that is relatively rare in other populations, worldwide. This study both 
      demonstrates and emphasizes the value of studying HLA class I polymorphism at 
      highest resolution in anthropologically well-defined populations.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Ashouri, E
AU  - Ashouri E
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, CA, USA.
AD  - Department of Microbiology and Immunology, Stanford University School of 
      Medicine, Stanford, CA, USA.
AD  - Endocrinology and Metabolism Research Center, Namazi Hospital, Shiraz University 
      of Medical Sciences, Shiraz, Iran.
FAU - Norman, P J
AU  - Norman PJ
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, CA, USA.
AD  - Department of Microbiology and Immunology, Stanford University School of 
      Medicine, Stanford, CA, USA.
FAU - Guethlein, L A
AU  - Guethlein LA
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, CA, USA.
AD  - Department of Microbiology and Immunology, Stanford University School of 
      Medicine, Stanford, CA, USA.
FAU - Han, A S
AU  - Han AS
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, CA, USA.
AD  - Department of Microbiology and Immunology, Stanford University School of 
      Medicine, Stanford, CA, USA.
FAU - Nemat-Gorgani, N
AU  - Nemat-Gorgani N
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, CA, USA.
AD  - Department of Microbiology and Immunology, Stanford University School of 
      Medicine, Stanford, CA, USA.
FAU - Norberg, S J
AU  - Norberg SJ
AD  - Illumina Inc, San Diego, CA, USA.
FAU - Ghaderi, A
AU  - Ghaderi A
AD  - Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Parham, P
AU  - Parham P
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, CA, USA.
AD  - Department of Microbiology and Immunology, Stanford University School of 
      Medicine, Stanford, CA, USA.
LA  - eng
GR  - R01 AI017892/AI/NIAID NIH HHS/United States
GR  - T32 GM007790/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20160824
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (Epitopes)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Alleles
MH  - Databases, Genetic
MH  - Epitopes/chemistry/immunology
MH  - *Ethnicity
MH  - Gene Expression
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-A Antigens/classification/*genetics/immunology
MH  - HLA-B Antigens/classification/*genetics/immunology
MH  - HLA-C Antigens/classification/*genetics/immunology
MH  - Haplotypes
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - Iran
MH  - Ligands
MH  - *Polymorphism, Genetic
MH  - Receptors, KIR/classification/*genetics/immunology
MH  - Sequence Analysis, DNA
MH  - Terminology as Topic
PMC - PMC5063635
MID - NIHMS821336
OTO - NOTNLM
OT  - Bw4 epitope
OT  - HLA class I polymorphism
OT  - HLA-B*51:01
OT  - Lur and Kurd populations
OT  - high-throughput sequencing
COIS- The authors have declared no conflicting interests.
EDAT- 2016/08/26 06:00
MHDA- 2018/01/19 06:00
PMCR- 2017/09/01
CRDT- 2016/08/26 06:00
PHST- 2016/05/10 00:00 [received]
PHST- 2016/07/10 00:00 [revised]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2016/08/26 06:00 [entrez]
PHST- 2016/08/26 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 10.1111/tan.12852 [doi]
PST - ppublish
SO  - HLA. 2016 Sep;88(3):87-99. doi: 10.1111/tan.12852. Epub 2016 Aug 24.