PMID- 27558074
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20181202
IS  - 1099-0844 (Electronic)
IS  - 0263-6484 (Linking)
VI  - 34
IP  - 6
DP  - 2016 Aug
TI  - Study of differentiated human umbilical cord-derived mesenchymal stem cells 
      transplantation on rat model of advanced parkinsonism.
PG  - 387-93
LID - 10.1002/cbf.3204 [doi]
AB  - The aim of this study was to explore the curative effect of differentiated human 
      umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation on rat 
      of advanced Parkinson disease (PD) model. Human umbilical cord-derived 
      mesenchymal stem cells were cultured and induced differentiation in vitro. The PD 
      rats were established and allocated randomly into 2 groups: differentiated 
      hUC-MSCs groups and physiological saline groups (the control group). Rotation 
      test and immunofluorescence double staining were done. The result showed that 
      hUC-MSCs could differentiate into mature dopamine neurons. Frequency of rotation 
      was significantly less in differentiated hUC-MSCs groups than in normal saline 
      group. After we transplanted these cells into the unilateral lesioned substantia 
      nigra induced by striatal injection of 6-hydroxydopamine and performed in the 
      medial forebrain bundle and ventral tegmental area, nigral tyrosine 
      hydroxylase-positive cells were observed and survival of at least 2 months. In 
      addition, transplantation of hUC-MSCs could make an obviously therapeutic effect 
      on PD rats.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Wang, Zhaowei
AU  - Wang Z
AD  - Dept of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei 
      Province, P. R .C;
FAU - Chen, Aimin
AU  - Chen A
AD  - Qianjiang Central Hospital, Qianjiang 433100, Hubei Province, P. R .C.
FAU - Yan, Shengjuan
AU  - Yan S
AD  - Qianjiang Central Hospital, Qianjiang 433100, Hubei Province, P. R .C.
FAU - Li, Chengyan
AU  - Li C
AD  - Dept of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei 
      Province, P. R .C;
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Biomarkers)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Biomarkers/metabolism
MH  - *Cell Differentiation
MH  - Cell Membrane/metabolism
MH  - Cells, Cultured
MH  - Disease Models, Animal
MH  - Dopamine/metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology
MH  - Neostriatum/metabolism/pathology
MH  - Parkinsonian Disorders/pathology/*therapy
MH  - Rats, Sprague-Dawley
MH  - Tyrosine 3-Monooxygenase/metabolism
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - Parkinson disease
OT  - human umbilical cord-derived mesenchymal stem cells
OT  - transplantation
OT  - tyrosine hydroxylase
EDAT- 2016/08/26 06:00
MHDA- 2017/02/01 06:00
CRDT- 2016/08/26 06:00
PHST- 2016/02/20 00:00 [received]
PHST- 2016/06/27 00:00 [revised]
PHST- 2016/06/28 00:00 [accepted]
PHST- 2016/08/26 06:00 [entrez]
PHST- 2016/08/26 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
AID - 10.1002/cbf.3204 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2016 Aug;34(6):387-93. doi: 10.1002/cbf.3204.