PMID- 27558675
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20190907
IS  - 1873-4294 (Electronic)
IS  - 1568-0266 (Linking)
VI  - 17
IP  - 4
DP  - 2017
TI  - Melatonin and Respiratory Diseases: A Review.
PG  - 467-488
AB  - Melatonin is an indoleamine with potent multifunctional biological and 
      pharmacological effects, both receptor dependent and receptor-independent 
      effects, including antioxidant, anticancer, antitumor, anti-inflammatory, 
      anti-aging, anti-diabetic, antiviral, neuroprotective activities. Melatonin 
      mitigates tissue injury via modification of abnormalities in redox status and 
      other biochemical markers. At the molecular level, the biological and 
      pharmacological activities of melatonin are attributed to the inhibition of 
      nuclear factor-kappaappa beta (NF-kappabeta), c-Fos over expression and down-regulation of 
      matrix metalloproteinases-3 (MMP-3), which are regulators of pro-inflammatory and 
      pro-fibrotic cytokines. There are numerous scientific reports on the therapeutic 
      potential of melatonin in treatment of asthma, respiratory diseases for 
      infections, chronic obstructive pulmonary disease, lung cancer, pleural cavity 
      diseases, as well as vascular pulmonary disease. In the present communication, we 
      systematically review the therapeutic potential of melatonin in the treatment of 
      respiratory diseases along with its molecular mechanism of actions.
FAU - Habtemariam, Solomon
AU  - Habtemariam S
FAU - Daglia, Maria
AU  - Daglia M
FAU - Sureda, Antoni
AU  - Sureda A
FAU - Selamoglu, Zeliha
AU  - Selamoglu Z
FAU - Gulhan, Mehmet Fuat
AU  - Gulhan MF
FAU - Nabavi, Seyed Mohammad
AU  - Nabavi SM
AD  - Applied Biotechnology Research Center, Baqiyatallah University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Lung Diseases/*drug therapy
MH  - Melatonin/adverse effects/metabolism/pharmacology/*therapeutic use
MH  - Plants/metabolism
EDAT- 2016/08/26 06:00
MHDA- 2017/02/10 06:00
CRDT- 2016/08/26 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2015/09/20 00:00 [revised]
PHST- 2015/12/13 00:00 [accepted]
PHST- 2016/08/26 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
PHST- 2016/08/26 06:00 [entrez]
AID - CTMC-EPUB-77972 [pii]
AID - 10.2174/1568026616666160824120338 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2017;17(4):467-488. doi: 10.2174/1568026616666160824120338.