PMID- 27559978
OWN - NLM
STAT- MEDLINE
DCOM- 20170208
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 34
DP  - 2016 Aug
TI  - Safety and feasibility of the RhinoChill immediate transnasal evaporative cooling 
      device during out-of-hospital cardiopulmonary resuscitation: A single-center, 
      observational study.
PG  - e4692
LID - 10.1097/MD.0000000000004692 [doi]
LID - e4692
AB  - We investigated feasibility and safety of the RhinoChill (RC) transnasal cooling 
      system initiated before achieving a protected airway during cardiopulmonary 
      resuscitation (CPR) in a prehospital setting.In out-of-hospital cardiac arrest 
      (OHCA), transnasal evaporative cooling was initiated during CPR, before a 
      protected airway was established and continued until either the patient was 
      declared dead, standard institutional systemic cooling methods were implemented 
      or cooling supply was empty. Patients were monitored throughout the hypothermia 
      period until either death or hospital discharge. Clinical assessments and 
      relevant adverse events (AEs) were documented over this period of time.In total 
      21 patients were included. Four were excluded due to user errors or meeting 
      exclusion criteria. Finally, 17 patients (f = 6; mean age 65.5 years, CI95%: 
      57.7-73.4) were analyzed. Device-related AEs, like epistaxis or nose whitening, 
      occurred in 2 patients. They were mild and had no consequence on the patient's 
      outcome. According to the field reports of the emergency medical services (EMS) 
      personnel, no severe technical problems occurred by using the RC device that led 
      to a delay or the impairment of quality of the CPR.Early application of the RC 
      device, during OHCA is feasible, safe, easy to handle, and does not delay or 
      hinder CPR, or establishment of a secure intubation. For efficacy and further 
      safety data additional studies will be needed.
FAU - Grave, Marie-Sophie
AU  - Grave MS
AD  - Department of Emergency Medicine, Medical University of Vienna Wiener 
      Berufsrettung, Municipal Ambulance Service, Vienna University Hospital St. 
      Polten, Karl-Landsteiner Medical University, Lower Austria Department of Internal 
      Medicine III, Divison of Gastroenterology and Hepatology, Medical University of 
      Vienna, Vienna, Austria.
FAU - Sterz, Fritz
AU  - Sterz F
FAU - Nurnberger, Alexander
AU  - Nurnberger A
FAU - Fykatas, Stergios
AU  - Fykatas S
FAU - Gatterbauer, Mathias
AU  - Gatterbauer M
FAU - Stattermayer, Albert Friedrich
AU  - Stattermayer AF
FAU - Zajicek, Andreas
AU  - Zajicek A
FAU - Malzer, Reinhard
AU  - Malzer R
FAU - Sebald, Dieter
AU  - Sebald D
FAU - van Tulder, Raphael
AU  - van Tulder R
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Ambulances
MH  - Austria/epidemiology
MH  - Cardiopulmonary Resuscitation/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Hypothermia, Induced/*instrumentation/methods
MH  - Male
MH  - Middle Aged
MH  - Out-of-Hospital Cardiac Arrest/*epidemiology/mortality/therapy
MH  - Patient Safety
MH  - Prospective Studies
PMC - PMC5400345
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/08/26 06:00
MHDA- 2017/02/09 06:00
PMCR- 2016/08/26
CRDT- 2016/08/26 06:00
PHST- 2016/08/26 06:00 [entrez]
PHST- 2016/08/26 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
PHST- 2016/08/26 00:00 [pmc-release]
AID - 00005792-201608230-00055 [pii]
AID - 10.1097/MD.0000000000004692 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Aug;95(34):e4692. doi: 10.1097/MD.0000000000004692.