PMID- 27560455
OWN - NLM
STAT- MEDLINE
DCOM- 20180301
LR  - 20220409
IS  - 1559-3126 (Electronic)
IS  - 1095-158X (Print)
IS  - 1095-158X (Linking)
VI  - 40
IP  - 1
DP  - 2017 Mar
TI  - Pupillometer-based neurofeedback cognitive training to improve processing speed 
      and social functioning in individuals at clinical high risk for psychosis.
PG  - 33-42
LID - 10.1037/prj0000217 [doi]
AB  - OBJECTIVE: Among individuals at clinical high risk (CHR) for psychosis, 
      processing speed (PS) has been related to social and role functioning regardless 
      of conversion to schizophrenia. This information processing dysfunction is a 
      gateway to broader behavioral deficits such as difficulty executing social 
      behaviors. We examined the feasibility of improving information processing 
      relevant to social situations in CHR, including its sustainability at 2-month 
      follow-up, and its association with concurrent social function. METHOD: This was 
      a double-blind RCT in which 62 CHR participants were randomized to Processing 
      Speed Training (PST) or an active control matched for training format and the 
      same dose and duration of treatment. PST is a tablet-based program that uses 
      pupillometry-based neurofeedback to continually adjust training parameters for an 
      optimal neurocognitive load and to improve visual scanning efficiency by 
      inhibiting selection of nonessential targets and discriminating figure-ground 
      details. RESULTS: The PST group showed faster motoric and nonmotoric PS at post 
      training and 2-month follow-up. At 2 month follow-up, the PST group reported 
      better overall social adjustment. Changes in PS from baseline to 2 months were 
      correlated with overall social adjustment and social avoidance in the entire 
      sample. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: This is the first study to 
      test focal neurofeedback-based cognitive training for PS deficits in the 
      putatively prodromal phase of schizophrenia to address associated social 
      morbidity. Targeting PS appears to be a promising pathway to decreasing 
      comorbidity and mitigating a risk factor for psychosis. (PsycINFO Database Record
CI  - (c) 2017 APA, all rights reserved).
FAU - Choi, Jimmy
AU  - Choi J
AD  - The Institute of Living at Hartford Hospital.
FAU - Corcoran, Cheryl M
AU  - Corcoran CM
AD  - Columbia Psychiatry, Columbia University Medical Center.
FAU - Fiszdon, Joanna M
AU  - Fiszdon JM
AD  - VA Connecticut Healthcare System, Yale University School of Medicine.
FAU - Stevens, Michael
AU  - Stevens M
AUID- ORCID: 0000-0002-3799-5465
AD  - The Institute of Living at Hartford Hospital.
FAU - Javitt, Daniel C
AU  - Javitt DC
AD  - Columbia Psychiatry, Columbia University Medical Center.
FAU - Deasy, Melissa
AU  - Deasy M
AD  - The Institute of Living at Hartford Hospital.
FAU - Haber, Lawrence C
AU  - Haber LC
AD  - The Institute of Living at Hartford Hospital.
FAU - Dewberry, Michael J
AU  - Dewberry MJ
AD  - The Institute of Living at Hartford Hospital.
FAU - Pearlson, Godfrey D
AU  - Pearlson GD
AD  - The Institute of Living at Hartford Hospital.
LA  - eng
GR  - R01 MH049334/MH/NIMH NIH HHS/United States
GR  - R03 MH108933/MH/NIMH NIH HHS/United States
GR  - K23 MH086755/MH/NIMH NIH HHS/United States
GR  - R01 MH107558/MH/NIMH NIH HHS/United States
GR  - R21 MH086125/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160825
PL  - United States
TA  - Psychiatr Rehabil J
JT  - Psychiatric rehabilitation journal
JID - 9601800
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cognitive Remediation/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Neurofeedback/*physiology
MH  - Prodromal Symptoms
MH  - Psychotic Disorders/*rehabilitation
MH  - Pupil/*physiology
MH  - Schizophrenia/*rehabilitation
MH  - *Social Behavior
MH  - Therapy, Computer-Assisted
MH  - Young Adult
PMC - PMC5326611
MID - NIHMS807996
EDAT- 2016/08/26 06:00
MHDA- 2018/03/02 06:00
PMCR- 2018/03/01
CRDT- 2016/08/26 06:00
PHST- 2016/08/26 06:00 [pubmed]
PHST- 2018/03/02 06:00 [medline]
PHST- 2016/08/26 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 2016-41328-001 [pii]
AID - 10.1037/prj0000217 [doi]
PST - ppublish
SO  - Psychiatr Rehabil J. 2017 Mar;40(1):33-42. doi: 10.1037/prj0000217. Epub 2016 Aug 
      25.