PMID- 27561388
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20231111
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Aug 26
TI  - The influence of the aortic valve angle on the hemodynamic features of the 
      thoracic aorta.
PG  - 32316
LID - 10.1038/srep32316 [doi]
LID - 32316
AB  - Since the first observation of a helical flow pattern in aortic blood flow, the 
      existence of helical blood flow has been found to be associated with various 
      pathological conditions such as bicuspid aortic valve, aortic stenosis, and 
      aortic dilatation. However, an understanding of the development of helical blood 
      flow and its clinical implications are still lacking. In our present study, we 
      hypothesized that the direction and angle of aortic inflow can influence helical 
      flow patterns and related hemodynamic features in the thoracic aorta. Therefore, 
      we investigated the hemodynamic features in the thoracic aorta and various aortic 
      inflow angles using patient-specific vascular phantoms that were generated using 
      a 3D printer and time-resolved, 3D, phase-contrast magnetic resonance imaging 
      (PC-MRI). The results show that the rotational direction and strength of helical 
      blood flow in the thoracic aorta largely vary according to the inflow direction 
      of the aorta, and a higher helical velocity results in higher wall shear stress 
      distributions. In addition, right-handed rotational flow conditions with higher 
      rotational velocities imply a larger total kinetic energy than left-handed 
      rotational flow conditions with lower rotational velocities.
FAU - Ha, Hojin
AU  - Ha H
AD  - POSTECH Biotech Center, Pohang University of Science and Technology, San 31, 
      Hyoja-dong, Pohang 790-784, South Korea.
FAU - Kim, Guk Bae
AU  - Kim GB
AD  - Asan Institute of Life Science, Asan Medical Center, University of Ulsan College 
      of Medicine, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea.
FAU - Kweon, Jihoon
AU  - Kweon J
AD  - Department of Cardiology, University of Ulsan College of Medicine, Asan Medical 
      Center, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea.
FAU - Lee, Sang Joon
AU  - Lee SJ
AD  - POSTECH Biotech Center, Pohang University of Science and Technology, San 31, 
      Hyoja-dong, Pohang 790-784, South Korea.
AD  - Department of Mechanical Engineering, Pohang University of Science and Technology 
      (POSTECH), San 31, Hyoja-dong, Pohang 790-784, South Korea.
FAU - Kim, Young-Hak
AU  - Kim YH
AD  - Department of Cardiology, University of Ulsan College of Medicine, Asan Medical 
      Center, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea.
FAU - Kim, Namkug
AU  - Kim N
AD  - Department of Convergence Medicine, University of Ulsan College of Medicine, Asan 
      Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea.
AD  - Department of Radiology, University of Ulsan College of Medicine, Asan Medical 
      Center, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea.
FAU - Yang, Dong Hyun
AU  - Yang DH
AD  - Department of Radiology, University of Ulsan College of Medicine, Asan Medical 
      Center, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, South Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160826
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Algorithms
MH  - Aorta, Thoracic/diagnostic imaging/*physiopathology
MH  - Aortic Valve/*abnormalities/diagnostic imaging/physiopathology
MH  - Aortic Valve Stenosis/diagnostic imaging/physiopathology
MH  - Bicuspid Aortic Valve Disease
MH  - Blood Flow Velocity
MH  - Heart Valve Diseases/diagnostic imaging/*physiopathology
MH  - *Hemodynamics
MH  - Humans
MH  - Imaging, Three-Dimensional/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Stress, Mechanical
PMC - PMC4999809
EDAT- 2016/08/27 06:00
MHDA- 2018/07/06 06:00
PMCR- 2016/08/26
CRDT- 2016/08/27 06:00
PHST- 2016/02/14 00:00 [received]
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/08/27 06:00 [entrez]
PHST- 2016/08/27 06:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
PHST- 2016/08/26 00:00 [pmc-release]
AID - srep32316 [pii]
AID - 10.1038/srep32316 [doi]
PST - epublish
SO  - Sci Rep. 2016 Aug 26;6:32316. doi: 10.1038/srep32316.