PMID- 27561780
OWN - NLM
STAT- MEDLINE
DCOM- 20170329
LR  - 20181202
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Linking)
VI  - 26
IP  - 3
DP  - 2017 Mar
TI  - Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve 
      growth factor, and neurotrophin-3 levels in children with 
      attention-deficit/hyperactivity disorder.
PG  - 355-363
LID - 10.1007/s00787-016-0898-2 [doi]
AB  - It has been suggested that neurotrophins are involved in the etiopathogenesis of 
      attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate 
      whether there are differences in serum brain-derived neurotrophic factor (BDNF), 
      glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and 
      neurotrophin-3 (NTF3) levels between children with ADHD and healthy controls. A 
      total of 110 treatment-naive children with the combined presentation of ADHD and 
      44 healthy controls aged 8-18 years were enrolled in this study. The severity of 
      ADHD symptoms was determined by scores on the Conners' Parent Rating 
      Scale-Revised Short and Conners' Teacher Rating Scale-Revised Short. The severity 
      of depression and anxiety symptoms of the children were evaluated by the 
      self-report inventories. Serum levels of neurotrophins were measured using 
      commercial enzyme-linked immunosorbent assay kits. The multivariate analysis of 
      covariance (MANCOVA) revealed a significant main effect of groups in the levels 
      of serum neurotrophins, an effect that was independent of age, sex, and the 
      severity of the depression and anxiety. The analysis of covariance (ANCOVA) 
      indicated that the mean serum GDNF and NTF3 levels of ADHD patients were 
      significantly higher than that of controls. However, serum BDNF and NGF levels 
      did not show any significant differences between groups. No correlations between 
      the levels of serum neurotrophins and the severity of ADHD were observed. These 
      results suggest that elevated serum GDNF and NTF3 levels may be related to ADHD 
      in children.
FAU - Bilgic, Ayhan
AU  - Bilgic A
AD  - Department of Child and Adolescent Psychiatry, Meram School of Medicine, 
      Necmettin Erbakan University, 42090, Meram/Konya, Turkey. bilgicayhan@yahoo.com.
FAU - Toker, Aysun
AU  - Toker A
AD  - Department of Biochemistry, Meram School of Medicine, Necmettin Erbakan 
      University, Konya, Turkey.
FAU - Isik, Umit
AU  - Isik U
AD  - Department of Child and Adolescent Psychiatry, Meram School of Medicine, 
      Necmettin Erbakan University, 42090, Meram/Konya, Turkey.
FAU - Kilinc, Ibrahim
AU  - Kilinc I
AD  - Department of Biochemistry, Meram School of Medicine, Necmettin Erbakan 
      University, Konya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160825
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (NGF protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Anxiety/diagnosis/psychology
MH  - Attention Deficit Disorder with Hyperactivity/*blood/etiology/pathology
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Child
MH  - Depression/diagnosis/psychology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor/*blood
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Nerve Growth Factor
MH  - Nerve Growth Factors/*blood/metabolism
MH  - Neurotrophin 3/*blood/metabolism
MH  - Self Report
OTO - NOTNLM
OT  - Attention-deficit/hyperactivity disorder
OT  - Brain-derived neurotrophic factor
OT  - Glial-derived neurotrophic factor
OT  - Nerve growth factor
OT  - Neurotrophin-3
EDAT- 2016/08/27 06:00
MHDA- 2017/03/31 06:00
CRDT- 2016/08/27 06:00
PHST- 2016/03/31 00:00 [received]
PHST- 2016/08/16 00:00 [accepted]
PHST- 2016/08/27 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
PHST- 2016/08/27 06:00 [entrez]
AID - 10.1007/s00787-016-0898-2 [pii]
AID - 10.1007/s00787-016-0898-2 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2017 Mar;26(3):355-363. doi: 
      10.1007/s00787-016-0898-2. Epub 2016 Aug 25.