PMID- 27562033
OWN - NLM
STAT- MEDLINE
DCOM- 20170220
LR  - 20181113
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 35
IP  - 10
DP  - 2016 Oct
TI  - Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid 
      syndrome patients.
PG  - 2485-93
LID - 10.1007/s10067-016-3369-8 [doi]
AB  - The aim of this study was to evaluate oxidative stress markers and it relations 
      to endothelial damage as risk factor for thrombosis in patients with primary 
      (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to 
      traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced 
      dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 
      SAPS) and 40 controls matched by age, sex, and conventional risk factors for 
      atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), 
      advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and 
      paraoxonase 1 activity (PON1) were determined by spectrophotometric method. 
      Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid 
      fractions (p < 0.05), unlike PON1, tSHG that correlated to antiphospholipid 
      antibody positivity (p < 0.05). FMD was lower in APS patients comparing to 
      controls (p < 0.001). Cholesterol is independent variable for FMD impairment in 
      control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides 
      in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined 
      predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both 
      PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, 
      p<0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent 
      predictor for endothelial dysfunction in APS patients. We demonstrated 
      synergistic effect of aCL and LOOH as risk for endothelial impairment in both 
      PAPS and SAPS patients.
FAU - Stanisavljevic, Natasa
AU  - Stanisavljevic N
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia. nacastanisavljevic@gmail.com.
FAU - Stojanovich, L
AU  - Stojanovich L
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia.
FAU - Marisavljevic, D
AU  - Marisavljevic D
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia.
AD  - Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Djokovic, A
AU  - Djokovic A
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia.
AD  - Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Dopsaj, V
AU  - Dopsaj V
AD  - Clinical Center of Serbia, Faculty of Pharmacy Belgrade, University of Belgrade, 
      Belgrade, Serbia.
FAU - Kotur-Stevuljevic, J
AU  - Kotur-Stevuljevic J
AD  - Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 
      Belgrade, Serbia.
FAU - Martinovic, J
AU  - Martinovic J
AD  - Rakovica Community Health Center, Belgrade, Serbia.
FAU - Memon, L
AU  - Memon L
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia.
FAU - Radovanovic, S
AU  - Radovanovic S
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia.
FAU - Todic, B
AU  - Todic B
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia.
FAU - Lisulov, D
AU  - Lisulov D
AD  - University Clinical Center "Bezanijska kosa", Bezanijska kosa bb, Belgrade, 
      11070, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20160825
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Biomarkers)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
SB  - IM
MH  - Adult
MH  - Antiphospholipid Syndrome/complications/metabolism/*physiopathology
MH  - Aryldialkylphosphatase/metabolism
MH  - Biomarkers
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Lipid Peroxidation/*physiology
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Risk Factors
MH  - Thrombosis/*etiology/metabolism/physiopathology
OTO - NOTNLM
OT  - Antiphospholipid syndrome
OT  - Endothelial dysfunction
OT  - Oxidative stress
OT  - Thrombosis
EDAT- 2016/08/27 06:00
MHDA- 2017/10/14 06:00
CRDT- 2016/08/27 06:00
PHST- 2016/04/15 00:00 [received]
PHST- 2016/07/25 00:00 [accepted]
PHST- 2016/06/06 00:00 [revised]
PHST- 2016/08/27 06:00 [entrez]
PHST- 2016/08/27 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
AID - 10.1007/s10067-016-3369-8 [pii]
AID - 10.1007/s10067-016-3369-8 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2016 Oct;35(10):2485-93. doi: 10.1007/s10067-016-3369-8. Epub 
      2016 Aug 25.