PMID- 27562197
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20180111
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 30
IP  - 12
DP  - 2016 Dec
TI  - Neurocognitive performance following acute mephedrone administration, with and 
      without alcohol.
PG  - 1305-1312
AB  - Recreational use of mephedrone, alone and in combination with alcohol, has 
      increased over the past years. Pharmacological properties of mephedrone share 
      similarities with methylenedioxymethamphetamine (MDMA), but its effect on 
      neurocognitive function has not been well established in humans. The present 
      study assessed the effect of mephedrone alone and after co-administration with 
      alcohol on neurocognitive function. It was hypothesised that mephedrone would 
      improve psychomotor performance but impair memory performance, when administered 
      alone. Neurocognitive performance was expected to be impaired following 
      mephedrone when combined with alcohol. Eleven participants received single doses 
      of 200 mg mephedrone or placebo combined with 0.8 g/kg alcohol or placebo. 
      Neurocognitive performance was assessed at baseline (T(0)), at one hour (T(1)) 
      and four hours after (T(2)) mephedrone administration, by means of the Divided 
      Attention Task (DAT), Critical Tracking Task (CTT), and the Spatial Memory Test 
      (SMT). Mephedrone intoxication impaired short-term spatial memory at T(1) and 
      improved critical tracking performance at T(2) Mephedrone alone did not affect 
      divided attention, but did show an interaction with alcohol on reaction time at 
      T(2) Reaction time decreased when mephedrone was combined with alcohol as 
      compared to alcohol alone. Alcohol intoxication impaired both short- and 
      long-term spatial memory at T(1) and divided attention at T(1) and T(2) Critical 
      tracking performance was not affected by alcohol intoxication. The current 
      findings support the hypothesis that mephedrone improves psychomotor performance, 
      impairs spatial memory and does not affect divided attention performance. 
      Stimulatory effects of mephedrone were not sufficient to compensate for the 
      impairing effects of alcohol on most performance parameters.
CI  - (c) The Author(s) 2016.
FAU - de Sousa Fernandes Perna, E B
AU  - de Sousa Fernandes Perna EB
AD  - Department of Neuropsychology and Psychopharmacology, Maastricht University, 
      Maastricht, the Netherlands e.desousafernandes@maastrichtuniversity.nl.
FAU - Papaseit, E
AU  - Papaseit E
AD  - Integrative Pharmacology & Neurosciences Systems Research Group, Institut 
      Hospital del Mar d'Investigacions Mediques, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Spain.
AD  - Hospital Universitari Germans Trias i Pujol, Clinical Pharmacology, Badalona, 
      Spain.
FAU - Perez-Mana, C
AU  - Perez-Mana C
AD  - Integrative Pharmacology & Neurosciences Systems Research Group, Institut 
      Hospital del Mar d'Investigacions Mediques, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Mateus, J
AU  - Mateus J
AD  - Integrative Pharmacology & Neurosciences Systems Research Group, Institut 
      Hospital del Mar d'Investigacions Mediques, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Theunissen, E L
AU  - Theunissen EL
AD  - Department of Neuropsychology and Psychopharmacology, Maastricht University, 
      Maastricht, the Netherlands.
FAU - Kuypers, Kpc
AU  - Kuypers K
AD  - Department of Neuropsychology and Psychopharmacology, Maastricht University, 
      Maastricht, the Netherlands.
FAU - de la Torre, R
AU  - de la Torre R
AD  - Integrative Pharmacology & Neurosciences Systems Research Group, Institut 
      Hospital del Mar d'Investigacions Mediques, Barcelona, Spain.
AD  - Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBEROBN), Santiago de Compostela, Spain.
AD  - Universitat Pompeu Fabra, CEXS-UPF, Barcelona, Spain.
FAU - Farre, M
AU  - Farre M
AD  - Integrative Pharmacology & Neurosciences Systems Research Group, Institut 
      Hospital del Mar d'Investigacions Mediques, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Spain.
AD  - Hospital Universitari Germans Trias i Pujol, Clinical Pharmacology, Badalona, 
      Spain.
FAU - Ramaekers, J G
AU  - Ramaekers JG
AD  - Department of Neuropsychology and Psychopharmacology, Maastricht University, 
      Maastricht, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160825
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 3K9958V90M (Ethanol)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Attention/drug effects
MH  - Cognition/*drug effects
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Ethanol/*pharmacology
MH  - Humans
MH  - Male
MH  - Memory, Short-Term/drug effects
MH  - Methamphetamine/*analogs & derivatives/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Psychomotor Performance/*drug effects
MH  - Reaction Time/drug effects
MH  - Young Adult
OTO - NOTNLM
OT  - Acute
OT  - alcohol co-administration
OT  - mephedrone
OT  - psychomotor performance
OT  - spatial memory
EDAT- 2016/08/27 06:00
MHDA- 2017/12/28 06:00
CRDT- 2016/08/27 06:00
PHST- 2016/08/27 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
PHST- 2016/08/27 06:00 [entrez]
AID - 0269881116662635 [pii]
AID - 10.1177/0269881116662635 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2016 Dec;30(12):1305-1312. doi: 10.1177/0269881116662635. Epub 
      2016 Aug 25.