PMID- 27562198
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20220114
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Print)
IS  - 0269-8811 (Linking)
VI  - 30
IP  - 12
DP  - 2016 Dec
TI  - The effects of MDMA on socio-emotional processing: Does MDMA differ from other 
      stimulants?
PG  - 1248-1258
AB  - +/-3,4-Methylenedioxymethamphetamine (MDMA) is a popular recreational drug that 
      enhances sociability and feelings of closeness with others. These "prosocial" 
      effects appear to motivate the recreational use of MDMA and may also form the 
      basis of its potential as an adjunct to psychotherapy. However, the extent to 
      which MDMA differs from prototypic stimulant drugs, such as dextroamphetamine, 
      methamphetamine, and methylphenidate, in either its behavioral effects or 
      mechanisms of action, is not fully known. The purpose of this review is to 
      evaluate human laboratory findings of the social effects of MDMA compared to 
      other stimulants, ranging from simple subjective ratings of sociability to more 
      complex elements of social processing and behavior. We also review the 
      neurochemical mechanisms by which these drugs may impact sociability. Together, 
      the findings reviewed here lay the groundwork for better understanding the 
      socially enhancing effects of MDMA that distinguish it from other stimulant 
      drugs, especially as these effects relate to the reinforcing and potentially 
      therapeutic effects of the drug.
CI  - (c) The Author(s) 2016.
FAU - Bershad, Anya K
AU  - Bershad AK
AD  - Department of Psychiatry and Behavioral Neuroscience.
AD  - Interdisciplinary Scientist Training Program; University of Chicago, Chicago, IL, 
      USA.
FAU - Miller, Melissa A
AU  - Miller MA
AD  - Department of Psychiatry and Behavioral Neuroscience.
FAU - Baggott, Matthew J
AU  - Baggott MJ
AD  - People Analytics, Genentech, South San Francisco, CA, USA.
FAU - de Wit, Harriet
AU  - de Wit H
AD  - Department of Psychiatry and Behavioral Neuroscience hdew@uchicago.edu.
LA  - eng
GR  - RC1 DA028129/DA/NIDA NIH HHS/United States
GR  - R21 DA026570/DA/NIDA NIH HHS/United States
GR  - T32 GM007281/GM/NIGMS NIH HHS/United States
GR  - T32 MH020065/MH/NIMH NIH HHS/United States
GR  - R01 DA002812/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20160825
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Central Nervous System Stimulants/*therapeutic use
MH  - Emotions/*drug effects
MH  - Hallucinogens/*therapeutic use
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*therapeutic use
MH  - Social Behavior
PMC - PMC8753974
MID - NIHMS1768076
OTO - NOTNLM
OT  - MDMA
OT  - amphetamines
OT  - emotion
OT  - social behavior
OT  - stimulants
COIS- Declaration of conflicting interests The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2016/08/27 06:00
MHDA- 2017/12/28 06:00
PMCR- 2022/01/12
CRDT- 2016/08/27 06:00
PHST- 2016/08/27 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
PHST- 2016/08/27 06:00 [entrez]
PHST- 2022/01/12 00:00 [pmc-release]
AID - 0269881116663120 [pii]
AID - 10.1177/0269881116663120 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2016 Dec;30(12):1248-1258. doi: 10.1177/0269881116663120. Epub 
      2016 Aug 25.