PMID- 27563001
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20181023
IS  - 2310-6972 (Print)
IS  - 2310-6905 (Linking)
VI  - 62
IP  - 4
DP  - 2016 May
TI  - [Biochemical and immunological markers of autoimmune thyroiditis].
PG  - 458-65
LID - 10.18097/PBMC20166204458 [doi]
AB  - Correlations between biochemical and immunological markers of programmed cell 
      death (apoptosis), and the functional state of the thyroid gland 
      (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in 
      autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). 
      Annexin V, TRAIL and TNF-a, as well as DNA-hydrolyzing antibodies were used as 
      the main markers. Increased levels of TRAIL were found in the serum of AT 
      patients (hyperthyroidism>hypothyroidism>euthyroidism) compared with healthy 
      individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had 
      the highest frequency in AT patients (97%) compared with healthy controls. Among 
      these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had 
      euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with 
      symptoms of the thyroid dysfunction.
FAU - Biktagirova, E M
AU  - Biktagirova EM
AD  - Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, 
      Kazan, Russia.
FAU - Sattarova, L I
AU  - Sattarova LI
AD  - Interregional Clinical Diagnostic Center, Kazan, Russia.
FAU - Vagapova, G R
AU  - Vagapova GR
AD  - Kazan State Medical Academy, Kazan, Russia.
FAU - Skibo, Y V
AU  - Skibo YV
AD  - Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, 
      Kazan, Russia.
FAU - Chuhlovina, E N
AU  - Chuhlovina EN
AD  - Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, 
      Kazan, Russia.
FAU - Kravtsova, O A
AU  - Kravtsova OA
AD  - Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, 
      Kazan, Russia.
FAU - Abramova, Z I
AU  - Abramova ZI
AD  - Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, 
      Kazan, Russia.
LA  - rus
PT  - Journal Article
TT  - Biokhimicheskie i immunologicheskie markery khronicheskogo limfotsitarnogo 
      tireoidita.
PL  - Russia (Federation)
TA  - Biomed Khim
JT  - Biomeditsinskaia khimiia
JID - 101196966
RN  - 0 (Annexin A5)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Annexin A5/blood
MH  - *Apoptosis
MH  - Autoantibodies/blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - DNA/immunology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Receptors, Tumor Necrosis Factor/blood
MH  - Thyroid Gland/*immunology
MH  - Thyroiditis, Autoimmune/*blood/immunology
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - antibodies to DNA
OT  - apoptosis
OT  - autoantibodies
OT  - autoimmune thyroiditis
EDAT- 2016/08/27 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/08/27 06:00
PHST- 2016/08/27 06:00 [entrez]
PHST- 2016/08/27 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
AID - 10.18097/PBMC20166204458 [doi]
PST - ppublish
SO  - Biomed Khim. 2016 May;62(4):458-65. doi: 10.18097/PBMC20166204458.