PMID- 27564669
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180924
IS  - 2325-6621 (Electronic)
IS  - 2325-6621 (Linking)
VI  - 13 Suppl 4
DP  - 2016 Aug
TI  - Alpha-1 Antitrypsin Deficiency: Phenotypes and Quality of Life.
PG  - S332-5
LID - 10.1513/AnnalsATS.201507-436KV [doi]
AB  - Alpha-1 antitrypsin deficiency (AATD) is a recognized genetic cause of rapidly 
      progressive loss of lung function conventionally assessed by the decline in FEV1. 
      However, there is less information concerning other physiological measures and 
      the impact on quality of life. Data derived predominantly from the UK national 
      registry show that AATD presents with various physiological phenotypes with 
      differing clinical impact and progression. In general, the decline in quality of 
      life is surprisingly slow despite rapid loss of lung function, which may reflect 
      the benefits of centralized services for patients with AATD. Use of the new GOLD 
      classification identifies patient characteristics that relate to mortality and 
      disparate symptomatology despite similar spirometric impairment.
FAU - Stockley, Robert A
AU  - Stockley RA
AD  - Lung Investigation Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, United 
      Kingdom.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Am Thorac Soc
JT  - Annals of the American Thoracic Society
JID - 101600811
SB  - IM
MH  - Age Factors
MH  - Health Status
MH  - Humans
MH  - Phenotype
MH  - Pulmonary Emphysema/etiology/mortality/*physiopathology
MH  - *Quality of Life
MH  - Spirometry
MH  - alpha 1-Antitrypsin Deficiency/complications/mortality/*physiopathology
OTO - NOTNLM
OT  - GOLD
OT  - alpha-1 antitrypsin deficiency
OT  - health status
OT  - lung function
EDAT- 2016/08/27 06:00
MHDA- 2018/01/06 06:00
CRDT- 2016/08/27 06:00
PHST- 2016/08/27 06:00 [entrez]
PHST- 2016/08/27 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 10.1513/AnnalsATS.201507-436KV [doi]
PST - ppublish
SO  - Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S332-5. doi: 
      10.1513/AnnalsATS.201507-436KV.