PMID- 27565327
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190107
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 63
IP  - 6
DP  - 2016
TI  - Potential key molecular correlations in laryngeal squamous cell carcinoma 
      revealed by integrated analysis of mRNA, miRNA and lncRNA microarray profiles.
PG  - 888-900
AB  - To uncover potential key genes, microRNAs (miRNAs) and long non-coding RNAs 
      (lncRNAs) associated with laryngeal squamous cell carcinoma (LSCC), microarray 
      data of mRNA, miRNAs and lncRNAs produced from matched sample pairs of LSCC and 
      adjacent normal samples were used to this analysis. Differentially expressed 
      genes (DEGs), miRNAs (DE-miRNAs) and lncRNAs (DE-lncRNAs) were identified, and 
      functions and correlations of them were analyzed. In total, 826 DEGs, 44 
      DE-miRNAs and 347 DE-lncRNAs were identified. The up-regulated DEGs were mainly 
      related to cell cycle, and the down-regulated DEGs were correlated with 
      regulation of biological quality and extracellular region. Furthermore, ATP1A2 
      was regulated by the lncRNA FLJ42875; AQP1 and TGFBR2 were targeted by 
      LOC100505976; genes like BUB1B and CENPE were modulated by XLOC_l2_010636. 
      Besides, genes like FGF2 and PIK3R1, and lncRNAs like LOC100505976 and 
      XLOC_l2_010636 were modulated by hsa-miR-424-5p. The expression levels of 
      hsa-miR-424-5p, LOC100505976 and XLOC_l2_010636 as well as several DEGs were 
      confirmed by quantitative real time polymerase chain reaction. These regulatory 
      relationships of DEGs, DE-miRNAs and DE-lncRNAs might play pivotal roles in the 
      tumorigenesis of LSCC.
FAU - Zhang, C
AU  - Zhang C
FAU - Gao, W
AU  - Gao W
FAU - Wen, S
AU  - Wen S
FAU - Wu, Y
AU  - Wu Y
FAU - Fu, R
AU  - Fu R
FAU - Zhao, D
AU  - Zhao D
FAU - Chen, X
AU  - Chen X
FAU - Wang, B
AU  - Wang B
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 0 (MIRN424 microrna, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Down-Regulation
MH  - *Gene Regulatory Networks
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - *MicroRNAs
MH  - Protein Array Analysis
MH  - *RNA, Long Noncoding
MH  - *RNA, Messenger
OTO - NOTNLM
OT  - differentially expressed gene
OT  - laryngeal squamous cell carcinoma
OT  - long non-coding RNA network.
OT  - microRNA
EDAT- 2016/08/28 06:00
MHDA- 2019/01/08 06:00
CRDT- 2016/08/28 06:00
PHST- 2016/08/28 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2016/08/28 06:00 [entrez]
AID - 10.4149/neo_2016_608 [doi]
PST - ppublish
SO  - Neoplasma. 2016;63(6):888-900. doi: 10.4149/neo_2016_608.