PMID- 27565903
OWN - NLM
STAT- MEDLINE
DCOM- 20171024
LR  - 20210109
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 4
IP  - 16
DP  - 2016 Aug
TI  - Increasing fetal ovine number per gestation alters fetal plasma clinical 
      chemistry values.
LID - 10.14814/phy2.12905 [doi]
LID - e12905
AB  - Intrauterine growth restriction (IUGR) is interconnected with developmental 
      programming of lifelong pathophysiology. IUGR is seen in human multifetal 
      pregnancies, with stepwise rises in fetal numbers interfering with placental 
      nutrient delivery. It remains unknown whether fetal blood analyses would reflect 
      fetal nutrition, liver, and excretory function in the last trimester of human or 
      ovine IUGR In an ovine model, we hypothesized that fetal plasma biochemical 
      values would reflect progressive placental, fetal liver, and fetal kidney 
      dysfunction as the number of fetuses per gestation rose. To determine fetal 
      plasma biochemical values in singleton, twin, triplet, and quadruplet/quintuplet 
      ovine gestation, we investigated morphometric measures and comprehensive 
      metabolic panels with nutritional measures, liver enzymes, and placental and 
      fetal kidney excretory measures at gestational day (GD) 130 (90% gestation). As 
      anticipated, placental dysfunction was supported by a stepwise fall in fetal 
      weight, fetal plasma glucose, and triglyceride levels as fetal number per ewe 
      rose. Fetal glucose and triglycerides were directly related to fetal weight. 
      Plasma creatinine, reflecting fetal renal excretory function, and plasma 
      cholesterol, reflecting placental excretory function, were inversely correlated 
      with fetal weight. Progressive biochemical disturbances and growth restriction 
      accompanied the rise in fetal number. Understanding the compensatory and adaptive 
      responses of growth-restricted fetuses at the biochemical level may help explain 
      how metabolic pathways in growth restriction can be predetermined at birth. This 
      physiological understanding is important for clinical care and generating 
      interventional strategies to prevent altered developmental programming in 
      multifetal gestation.
CI  - (c) 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on 
      behalf of the American Physiological Society and The Physiological Society.
FAU - Zywicki, Micaela
AU  - Zywicki M
AD  - Departments of Pediatrics, University of Wisconsin-Madison School of Medicine and 
      Public Health, Madison, WI, USA.
FAU - Blohowiak, Sharon E
AU  - Blohowiak SE
AD  - Departments of Pediatrics, University of Wisconsin-Madison School of Medicine and 
      Public Health, Madison, WI, USA.
FAU - Magness, Ronald R
AU  - Magness RR
AD  - Departments of Pediatrics, University of Wisconsin-Madison School of Medicine and 
      Public Health, Madison, WI, USA Obstetrics and Gynecology Perinatal Research 
      Laboratories, University of Wisconsin-Madison School of Medicine and Public 
      Health, Madison, WI, USA.
FAU - Segar, Jeffrey L
AU  - Segar JL
AD  - Department of Pediatrics, University of Iowa Children's Hospital, Iowa, IA, USA.
FAU - Kling, Pamela J
AU  - Kling PJ
AD  - Departments of Pediatrics, University of Wisconsin-Madison School of Medicine and 
      Public Health, Madison, WI, USA pkling@pediatrics.wisc.edu.
LA  - eng
GR  - R01 HL117341/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
SB  - IM
MH  - Animals
MH  - Chemistry, Clinical
MH  - Female
MH  - Fetal Blood/*chemistry/metabolism
MH  - Fetal Development/*physiology
MH  - Fetal Growth Retardation/blood/metabolism/*physiopathology
MH  - Fetus/metabolism/*physiology
MH  - Gestational Age
MH  - Organ Size
MH  - Placenta/metabolism/*physiology
MH  - Pregnancy
MH  - *Pregnancy, Animal
MH  - Pregnancy, Multiple/*physiology
MH  - Sheep
MH  - Sheep, Domestic/*growth & development/physiology
PMC - PMC5002913
OTO - NOTNLM
OT  - Fetal
OT  - nutrition
OT  - ovine
OT  - placenta
EDAT- 2016/08/28 06:00
MHDA- 2017/10/25 06:00
PMCR- 2016/08/26
CRDT- 2016/08/28 06:00
PHST- 2016/06/08 00:00 [received]
PHST- 2016/07/27 00:00 [accepted]
PHST- 2016/08/28 06:00 [entrez]
PHST- 2016/08/28 06:00 [pubmed]
PHST- 2017/10/25 06:00 [medline]
PHST- 2016/08/26 00:00 [pmc-release]
AID - 4/16/e12905 [pii]
AID - PHY212905 [pii]
AID - 10.14814/phy2.12905 [doi]
PST - ppublish
SO  - Physiol Rep. 2016 Aug;4(16):e12905. doi: 10.14814/phy2.12905.