PMID- 27566095
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20170302
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Linking)
VI  - 30
IP  - 5
DP  - 2016 09-10
TI  - Benefit of Patients with an Early and Progressed State of Hepatocellular 
      Carcinoma Treated with Drug-eluting Beads.
PG  - 707-12
AB  - AIM: To evaluate drug-eluting beads (DEB) for transarterial chemoembolization 
      (TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) A to D suffering 
      from hepatocellular carcinoma. MATERIAL AND METHODS: The progression-free 
      interval (PFI), survival and laboratory findings of 46 patients were 
      retrospectively analyzed after DEB TACE. RESULTS: The mean survival interval was 
      16.93 months. The BCLC A/B group had significantly (p=0.01) longer survival 
      compared to C/D: 20.44 and 10.36 months. Mean PFI was 10.75 months with a 
      significantly (p=0.002) longer PFI of the BCLC A/B group (12.71 months) compared 
      to BCLC C/D (3.91 months). In terms of possible adverse events (AEs) significant 
      changes (p<0.05) were observed in cholinesterase, white blood cells, alkaline 
      phosphatase and C-reactive protein. CONCLUSION: Mean survival and PFI results in 
      the BCLC A/B patient group were comparable to historical controls. In addition, 
      the results suggest that patients with BCLC stage C/D also benefited from DEB 
      TACE.
CI  - Copyright (c) 2016 International Institute of Anticancer Research (Dr. John G. 
      Delinassios), All rights reserved.
FAU - Rathmann, Nils
AU  - Rathmann N
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany 
      nils.rathmann@umm.de.
FAU - Sadick, Maliha
AU  - Sadick M
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Rathmann, Bjoern
AU  - Rathmann B
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Kostrzewa, Michael
AU  - Kostrzewa M
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Weiss, Christel
AU  - Weiss C
AD  - Department of Biomathematics, University Medical Center Mannheim, Medical Faculty 
      Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Schoenberg, Stefan O
AU  - Schoenberg SO
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Diehl, Steffen J
AU  - Diehl SJ
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Antoni, Christoph
AU  - Antoni C
AD  - Department of Internal Medicine II, Division of Gastroenterology and Hepatology, 
      University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg 
      University, Mannheim, Germany.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/*drug therapy/pathology
MH  - Chemoembolization, Therapeutic
MH  - Disease-Free Survival
MH  - Doxorubicin/*administration & dosage
MH  - Drug-Eluting Stents
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*drug therapy/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BCLC
OT  - HKLC
OT  - Hepatocellular carcinoma
OT  - TACE
OT  - tolerance
EDAT- 2016/08/28 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/08/28 06:00
PHST- 2016/04/27 00:00 [received]
PHST- 2016/06/06 00:00 [accepted]
PHST- 2016/08/28 06:00 [entrez]
PHST- 2016/08/28 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
AID - 30/5/707 [pii]
PST - ppublish
SO  - In Vivo. 2016 09-10;30(5):707-12.